Actively Recruiting
China Imaging-based Biobank of Cerebral Small Vessel Diseases A National Study to Evaluate Imaging and Clinical Outcomes
Led by Peking University Third Hospital · Updated on 2021-07-14
10000
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
P
Peking University Third Hospital
Lead Sponsor
B
Beijing Tiantan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are building a national comprehensive platform to evaluate cerebral small vessel diseases (CSVD) by collecting imaging-based medical data over time. This study aims to propose new classification and diagnostic criteria, establish risk prediction models, and identify high-risk populations early to reduce the future burden of CSVD in China. The study explores multiple factors including imaging signs, cognition, gait, autonomic nervous system, hemodynamics, sleep, emotion, and eye health. Participants with CSVD will be observed without intervention. The study involves longitudinal data collection including imaging and clinical assessments. The primary group consists of patients with CSVD as identified by MRI. Data on different CSVD types and their risk factors will be gathered to support the development of new diagnostic and prognostic tools. During participation, patients will undergo evaluations including MRI scans and assessments of neurological function, cognition, gait, and other health measures. Researchers will monitor outcomes such as the number of patients diagnosed, functional status (mRS score) over five years, and new vascular events. Participation involves long-term follow-up to study disease progression and outcomes, with no treatment administered as part of the study.
CONDITIONS
Brief Title
China Imaging-based Biobank of Cerebral Small Vessal Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Evidence of small vessel disease lesions on head MRI, including white matter hyperintensity with Fazekas score 2 or higher
- Fazekas score 1 with more than 2 vascular risk factors or combined with lacunar focus
- Imaging signs of new subcortical lacunar infarction
- Independent in daily life with modified Rankin Scale (mRS) score of 2 or less
- Signed informed consent
You will not qualify if you...
- Acute cerebral infarction with lesion larger than 20 mm on DWI
- Acute cerebral hemorrhage
- Acute or previous subarachnoid hemorrhage, cerebrovascular malformations, or untreated aneurysms larger than 3 mm
- Diagnosed neurodegenerative diseases such as Alzheimer's or Parkinson's disease
- Non-angiogenic white matter lesions like multiple sclerosis or metabolic encephalopathy
- Mental disorders diagnosed by DSM-V criteria
- Contraindications to MRI such as claustrophobia
- Severe organic diseases including malignant tumors with expected survival less than 5 years
- Unable to complete follow-up due to geographic or other reasons
- Participation in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 weeks
Participants undergo imaging and clinical assessments to evaluate cerebral small vessel diseases and related factors.
1 to 2 visits depending on assessments
Duration - Up to 5 years after diagnosis
Participants are monitored over several years to evaluate clinical outcomes such as vascular events and functional status.
Periodic visits during 5 years for outcome assessments
Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here