Actively Recruiting
China Longitudinal Aging and Cognitive Impairment Study
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2022-07-21
4000
Participants Needed
2
Research Sites
307 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead Sponsor
T
The Central Hospital of Lishui City
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multi-center longitudinal study that consists of five cohorts: cognitive normal aging (CN), Subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and vascular cognitive impairment (VCI). The goals of this study are as follow: 1.To establish longitudinal cohort study database containing comprehensive epidemiological data, neuropsychological test data, laboratory parameters, image data and biological samples. 2. To determine the risk factors of AD and other dementias. 3. To explore the conversion rates from CN to SCI, MCI or AD and the risk factors as well as biomarkers for the progression from CN to SCI, MCI or AD. 4. To explore and validate blood, CSF, urine, imaging and other biomarkers for the early detection and progression of AD.
CONDITIONS
Official Title
China Longitudinal Aging and Cognitive Impairment Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 40 years and older for CN, SCI, MCI, and VCI groups; 50 years and older for AD group
- Cognitive normal aging (CN) participants have MMSE score 6;22 and no cognitive impairment
- Subjective cognitive impairment (SCI) participants must have no dementia, normal cognitive test performance, and self-experienced persistent cognitive decline
- Mild cognitive impairment (MCI) participants diagnosed by 2004 Peterson's criteria with Clinical Dementia Rating (CDR) = 0.5 and memory loss
- Alzheimer's disease (AD) participants diagnosed by DSM-IV-R and NINCDS-ADRDA or NIA-AA criteria, able to complete examinations and provide consent
- Vascular cognitive impairment (VCI) participants diagnosed by small vessel VCI criteria, with cognitive impairment lasting 3 months or more and specific MRI findings
- All participants or their legal guardians must provide informed consent
You will not qualify if you...
- Presence of diseases causing cognitive impairment, such as dementia with Lewy bodies, frontotemporal dementia, Parkinson's disease dementia, severe brain trauma, or cerebrovascular disease with symptoms
- History of severe central nervous system infections, autoimmune encephalitis, epilepsy, or multiple sclerosis
- Systemic diseases affecting the central nervous system or abnormal liver/kidney functions
- History of hereditary diseases affecting cognition, such as Huntington's disease or Down syndrome
- Long-term heavy alcohol use
- Severe pulmonary or cardiovascular diseases
- Immune-related diseases affecting the central nervous system
- Metabolic or endocrine disorders requiring new or adjusted treatment
- Unstable psychosis or long-term antipsychotic use
- Active malignant tumors within the past year
- Contraindications to MRI or inability to cooperate with PET scans
- Illiteracy, hearing or visual impairments, poor coordination
- Refusal to participate or withdraw from the study
- For SCI and MCI: history of stroke with neurological signs, other neurological or systemic diseases causing cognitive impairment, mental retardation, contraindications to MRI, refusal to draw blood or consent
- For AD and VCI: other neurological or systemic diseases causing cognitive impairment, hereditary small vessel diseases, contraindications to MRI, refusal to draw blood or consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
2
Zhejiang Lishui central Hospital
Lishui, Zhejiang, China, 323000
Actively Recruiting
Research Team
Q
Qing-Qing Tao, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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