Actively Recruiting
China Longitudinal Aging and Cognitive Impairment Study
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2022-07-21
4000
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead Sponsor
T
The Central Hospital of Lishui City
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a multi-center longitudinal study focused on aging and cognitive impairment, including groups with normal cognitive aging, subjective cognitive impairment, mild cognitive impairment, Alzheimer's disease, and vascular cognitive impairment. The study aims to create a detailed database with epidemiological, neuropsychological, laboratory, imaging, and biological sample data. It also seeks to identify risk factors and biomarkers related to Alzheimer's disease and other dementias, as well as to measure conversion rates between cognitive stages over time. Participants will be categorized into one of five cohorts based on cognitive status and diagnostic criteria. They will be followed for up to five years, with data collected at baseline and follow-up visits. Collected data include medical histories, MRI and PET scans, genetic information, and biological samples such as blood, cerebrospinal fluid, and urine. This study does not involve any interventions but focuses on observing and tracking changes in cognition and related biomarkers. During the study, participants will undergo comprehensive assessments including cognitive testing, imaging scans, and biomarker analysis. Researchers will monitor the prevalence and incidence of cognitive impairment and dementia, the progression from normal cognition to more severe conditions, and relevant biomarkers in fluid and imaging studies. Additional measures include tracking gut microbiota and gait changes. The total involvement may last up to five years, with ongoing evaluations to better understand aging and cognitive decline.
CONDITIONS
Brief Title
China Longitudinal Aging and Cognitive Impairment Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 99 years
- Participants with normal cognitive function (MMSE ≥ 22) without impairment
- Participants with subjective cognitive concerns without dementia
- Participants diagnosed with mild cognitive impairment based on established criteria
- Participants aged 50 and older diagnosed with Alzheimer's disease
- Participants diagnosed with vascular cognitive impairment according to specified vascular and cognitive criteria
- Ability to complete required examinations and sign informed consent
You will not qualify if you...
- Presence of diseases causing cognitive impairment such as dementia with Lewy bodies, frontotemporal dementia, Parkinson's disease dementia, severe brain trauma, or cerebrovascular disease with symptoms
- History of severe central nervous system infections, autoimmune encephalitis, or epilepsy
- Systemic diseases affecting the brain, including severe liver or kidney dysfunction
- History of hereditary diseases affecting cognition like Huntington's disease or Down syndrome
- Long-term heavy alcohol use
- History of severe pulmonary or cardiovascular disease
- Immune-related diseases affecting the brain
- Metabolic or endocrine disorders requiring new or adjusted treatment
- Unstable psychosis or long-term antipsychotic use
- Recent active malignant tumors
- Contraindications for MRI or inability to cooperate with imaging
- Illiteracy or significant sensory impairments
- Refusal to participate or withdraw from the study
- History of stroke with neurological deficits or other neurological diseases causing brain dysfunction
- Systemic diseases causing cognitive impairment
- Mental or neurodevelopmental retardation
- Refusal to provide blood samples or sign consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 month
Participants undergo collection of epidemiological data, medical history, imaging scans (MRI and PET), genetic information, and biological samples.
1 baseline visit (in-person)
Duration - Up to 5 years
Participants are followed up over time with repeated assessments to monitor cognitive status and collect data including imaging and biological samples.
Follow-up visits at designated time points for up to 5 years
Trial Site Locations
Total: 2 locations
1
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
2
Zhejiang Lishui central Hospital
Lishui, Zhejiang, China, 323000
Actively Recruiting
Research Team
Q
Qing-Qing Tao, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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