Actively Recruiting
China Takayasu Arteritis Registry (CTA Registry)
Led by Aimin Dang · Updated on 2016-11-16
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Takayasu arteritis (TA) is a rare chronic inflammation affecting the aorta and its main branches, mostly occurring in China. Researchers aim to better understand the disease's characteristics, diagnosis, activity, severity, treatment, and outcomes in Chinese patients by building a national registry. Previous studies identified certain gene alleles linked to TA and found cytokines like hs-CRP, NT-proBNP, and tumor necrosis factor-alpha useful for monitoring disease activity, but more research is needed to clarify its causes and effects. This observational study collects real-world information from Chinese TA patients to analyze disease features and support the development of effective monitoring and treatment strategies. There are no specific treatments or interventions assigned; instead, data regarding patients' conditions and outcomes are recorded over time to gain insights. Participants will be followed for up to 10 years, during which the researchers will track mortality and major cardiac and cerebrovascular events. The study gathers detailed clinical data, including disease activity markers and treatment responses, to understand patient outcomes better. The long-term follow-up aims to improve knowledge for managing TA and improving patient care.
CONDITIONS
Brief Title
China Takayasu Arteritis Registry (CTA Registry)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at disease onset less than 40 years
- Development of symptoms or findings related to Takayasu arteritis before age 40
- Claudication of extremities, meaning fatigue and discomfort in muscles of one or more limbs during use
- Decreased pulse in one or both brachial arteries
- Difference greater than 10 mm Hg in systolic blood pressure between arms
- Audible bruit on auscultation over one or both subclavian arteries or abdominal aorta
- Abnormal arteriogram showing narrowing or blockage of the aorta, its main branches, or large arteries in limbs, excluding arteriosclerosis or similar causes
You will not qualify if you...
- Vessel lesions that could be entirely caused by atherosclerosis
- Giant cell arteritis or other infectious forms of large vessel vasculitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants who are registered in the Chinese national Takayasu arteritis registry are observed to collect real-world information on disease characteristics, diagnosis, activity, severity, treatment, and outcomes over time.
Periodic visits as part of routine clinical follow-up
Trial Site Locations
Total: 1 location
1
Fuwai Hospital
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
Research Team
A
Aimin Dang, MD,PhD
N
Naqiang lv, MD,PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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