Actively Recruiting
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Led by First Affiliated Hospital of Zhejiang University · Updated on 2022-10-17
10000
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers. It is believed that genetic and environmental factors are involved in the development of affective disorders. Gut microbes can affect the function of brain neural circuits by mediating metabolic, immune, endocrine and autonomic changes along the brain-gut axis. The brain can also regulate intestinal microbes through endocrine, neural structure, neurogenic exosomes and other pathways. Based on the brain-gut axis, this study intends to establish a large cohort of affective disorders, and screen out efficient and convenient biomarkers for clinical diagnosis and efficacy prediction by studying key indicators such as intestinal microbes, serum metabolites and immune indexes, brain-derived exosomes, and brain functional imaging.
CONDITIONS
Official Title
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both biological parents are Han nationality
- Aged 16 to 65 years
- Meet DSM-5 clinical diagnostic criteria for depressive episodes of major depressive disorder or bipolar disorder
- Have not taken immunomodulatory medications within 1 month before enrollment
- No clear history of respiratory, urinary, or digestive infections within 1 month before enrollment
You will not qualify if you...
- Diagnosed with schizophrenia spectrum, neurodevelopmental disorders, dementia, memory impairment, or other cognitive impairments per DSM-5
- Mental disorders caused by substance abuse, or serious physical or immune system diseases such as diabetes, thyroid diseases, hypertension, heart disease, liver or kidney dysfunction, autoimmune diseases
- Received antidepressants, antipsychotics, mood stabilizers, or similar medications within 1 month before enrollment
- Previously treated with electroconvulsive therapy
- Currently have serious suicidal thoughts, behaviors, or severe excitement
- Unable to follow doctor's advice or lack a guardian
- Pregnant, breastfeeding, or planning to become pregnant
- Have contraindications to MRI examination
- Any other condition the researcher deems inappropriate for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
S
Shaohua Hu
CONTACT
Y
Yanmeng Pan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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