Effect of a System-wide Multifaceted Quality Improvement Intervention on Thromboprophylaxis in Hospitalized Patients in China

What this Trial Is About

The trial investigates hospital-acquired venous thromboembolism (VTE) prevention among hospitalized patients in China, focusing on improving the use of preventive methods that are currently underutilized despite being safe and effective. This cluster-randomized clinical trial aims to evaluate whether a multifaceted quality improvement (QI) intervention is feasible and applicable in real-world hospital settings across China. The study is conducted within the China Pulmonary Thromboembolism Registry Study (CURES) group and seeks to increase the rate of at-risk patients receiving appropriate prophylaxis and reduce the incidence of hospital-associated VTE within 90 days after admission. Participating hospitals are randomized into two groups: an interventional group receiving multifaceted QI interventions and a control group following routine VTE prophylaxis based on current guidelines. The QI interventions include mandatory risk assessments, a computer alert system with clinical decision support and reminders, education initiatives, audit and feedback, distribution of clinical guidelines and pathways, and a mobile application to facilitate VTE risk assessment and communication between patients and physicians. The control group receives standard care or existing policies without these additional supports. During the study, eligible hospitalized patients will be monitored for appropriate prophylaxis use and the occurrence of VTE events, both symptomatic and asymptomatic, up to 90 days after hospital admission. Researchers will collect data on prophylaxis rates, VTE incidence, all-cause mortality, and complications related to the interventions. Weekly feedback reports will be provided to quality-control teams to ensure adherence to protocols. The total participation period includes hospitalization and a follow-up of 90 days post-admission, with various assessments and educational activities throughout the study.

CHIPs-VTE Study in Hospitalized Patients to Prevent Hospital-Acquired Venous Thromboembolism