Study of Chlordecone Exposure and Prostate Cancer Risk in Men Living in Martinique Under Age 75

What this Trial Is About

Prostate cancer is the most common cancer among men in industrialized countries like France and is the third leading cause of cancer-related death in men. This research investigates the possible link between exposure to chlordecone, an insecticide used in the French West Indies until 1993, and prostate cancer in Martinique. The study also considers other environmental factors and genetic variants that may influence prostate cancer risk, especially among men of Afro-Caribbean origin, who have higher incidence rates. The study is observational and includes three groups of adult men under 75 years old residing in Martinique for at least six months those newly diagnosed with prostate cancer, those with a negative prostate biopsy after elevated PSA levels, and those with PSA levels below 2.5 ngml. Participants will provide a blood sample for chlordecone measurement and complete a questionnaire during a single inclusion visit over a 36-month recruitment period. Participants will be assessed for chlordecone and other pollutant exposure, serum Prostate-Specific Antigen levels, and prostate cancer aggressiveness through medical records and imaging data. Additional analyses include studying chlordecone distribution in blood and tissues, molecular signatures in tumor tissues, and genotyping genetic variants. The research team will analyze the collected data after the recruitment to explore the association between chlordecone exposure and prostate cancer risk.

CHLORDECONE EXPOSURE AND PROSTATE CANCER IN THE FRENCH REGION OF MARTINIIQUE