Using Chlorhexidine Antiseptic Irrigation During and After Radical Cystectomy for Patients with Bladder Cancer Undergoing Urinary Diversion

What this Trial Is About

Researchers are evaluating the use of chlorhexidine antiseptic irrigation during and after surgery in patients undergoing radical cystectomy with urinary diversion for bladder cancer. This pilot interventional study aims to increase the rate of urine sterilization and reduce urinary tract infections within 30 days after surgery by applying an antimicrobial irrigation solution called Irrisept4. Patients will receive irrigation with 50 7 25 ml of Irrisept4 during surgery for a contact time of 2 minutes on the bowel segment used for urinary diversion. After surgery, those with ileal conduits will have daily irrigation for about 10 days, while those with ileal neobladders will continue irrigation daily for about 21 days. This irrigation schedule corresponds to the typical time when stents and catheters are removed. Participants will be monitored through urine cultures taken around 30 days after surgery to assess sterilization and track symptomatic urinary tract infections. Other outcomes include measuring urine leaks, incidence of sepsis, and infection rates within the first month post-operation. The study will last throughout the irrigation period and includes follow-up assessments to evaluate infection and safety outcomes.

Chlorhexidine Antiseptic Irrigation of the Bowel Segment During Radical Cystectomy and Urinary Diversion