Actively Recruiting
Comparing Chlorhexidine Versus Saline Irrigation During Colorectal Cancer Surgery a Multicenter Randomized Controlled Trial
Led by Nanchong Central Hospital · Updated on 2026-03-31
532
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of chlorhexidine compared to saline for flushing the surgical area during colorectal cancer surgery. This study aims to see if chlorhexidine irrigation can reduce surgical site infections and postoperative complications in patients undergoing colorectal cancer surgery. The trial includes diabetic and non-diabetic patients with either colon or rectal cancer, with a focus on surgical outcomes within 30 days after surgery. Participants will be randomly assigned to receive either chlorhexidine or saline irrigation after their colorectal cancer surgery. The chlorhexidine solution is applied to the surgical area for about one minute before the skin is sutured. The amount and duration of flushing may vary based on factors such as abdominal contamination, bleeding, and tumor invasion to ensure a clear surgical field free of blood, tissue fragments, or infection. During the study, researchers will monitor participants for surgical site infections and other postoperative complications within 30 days after surgery. The study uses a double-blind design to reduce bias. Participants must be between 18 and 85 years old, have resectable colorectal tumors confirmed by imaging, and meet certain health and anesthesia status criteria. They will be followed up to assess the number of infections and complications related to the surgery and irrigation method used.
CONDITIONS
Brief Title
Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-85 years
- Surgically resectable colorectal tumors confirmed by CT or MRI before surgery
- Performance status score of 0 or 1 according to the Eastern Tumor Cooperative group
- American Society of Anesthesiology grade I-III
You will not qualify if you...
- Tumor may have distant metastasis
- History of previous abdominal surgery
- History of other malignant tumors diagnosed in the past 5 years and prior radiotherapy or chemotherapy
- Obvious contraindications to surgery such as abnormal liver or kidney function or pregnancy
- Participation in other clinical trials within the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and immediate post-operative period
Participants undergo colorectal cancer surgery during which the surgical area is flushed with either chlorhexidine solution or saline shortly before skin closure. The flushing time and volume vary based on abdominal cavity contamination, bleeding, and tumor invasion to ensure a clear surgical field.
1 surgical procedure visit
Duration - 30 days
Participants are monitored for surgical site infections and postoperative complications following surgery.
Follow-up visits within 30 days after surgery
Trial Site Locations
Total: 1 location
1
Nanchong Central Hospital
Nanchong, Sichuan, China, 637000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
8
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