Actively Recruiting

Phase Not Applicable
Age: 18Years - 45Years
FEMALE
Healthy Volunteers
ID07065461

The Impact of Almond Size in a White Chocolate Matrix on Satiation, Postprandial Glycemia & Lipemia, Chewing Exertion, Eating Rate, and Product Liking: A Randomized Crossover Trial

Led by University of Guelph · Updated on 2025-07-15

35

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to understand how chewing behaviors relate to food intake and post-meal responses in healthy young adult females. It focuses on whether the presence or form of almonds (whole vs. chopped) in a white chocolate matrix affects how much participants eat and their feelings of fullness. The study also examines links between chewing patterns, satiation, and changes in blood sugar, blood fats, and satiety ratings after eating. Participants will attend the research center on three separate occasions while fasting to consume different types of white chocolate bark: one with whole almonds, one with chopped almonds, and one with no almonds. Each serving is offered in an ad libitum (eat as much as desired) style with a fixed ratio of chocolate to almonds where applicable. Researchers will measure the amount eaten, eating duration, and collect participants' ratings of chewing effort, enjoyment, and reasons for stopping eating. Finger prick blood samples will be taken before and after each meal to measure glucose and triacylglycerol levels. During each visit, participants complete questionnaires about their chewing experience and feelings of fullness up to 180 minutes after eating. Blood samples are collected at baseline, 120 minutes for glucose, and 180 minutes for triacylglycerols to assess metabolic responses. The study aims to provide insights into how food texture influences eating behavior and metabolism, which could guide better food choices to support heart and metabolic health. This trial is sponsored by the University of Guelph and complements related sensory and digestion studies.

CONDITIONS

Brief Title

The Chocolate Almond Study - Relating Chewing to Satiation and Postprandial Response

Who Can Participate

Age: 18Years - 45Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Female aged between 18 and 45 years
  • Body mass index between 18.5 and 27.9 kg/m2 or waist circumference less than 88 cm
  • No known food allergies or sensitivities
  • Non-restrained eaters based on the Three Factor Eating Questionnaire
  • No history of gastrointestinal diseases affecting eating or digestion
  • Stable medication use that does not affect appetite, digestion, blood sugar, saliva, or chewing
  • Non-smoker
  • No significant weight gain or loss in the past 3 months
  • Regular monthly menstrual cycles
  • Not pregnant, lactating, or post-menopausal
Not Eligible

You will not qualify if you...

  • Diabetes or other metabolic disorders affecting blood sugar or heart health
  • Any food allergies, intolerances, or life-threatening allergies
  • Pregnant or breastfeeding
  • Participation in another clinical trial
  • Alcohol consumption over 14 drinks per week
  • Smoking history or smoker for more than 10 years
  • Regular recreational drug use
  • Restrained eaters as defined by questionnaire score over 15
  • Unusual sleep patterns or irregular breakfast habits
  • Recent or intended weight change over 10% in 6 months
  • Use of medications affecting appetite, digestion, blood sugar, lipids, or chewing (except oral contraceptives)
  • Dry mouth symptoms or diagnosed Sjogren's Syndrome
  • Inability to follow study procedures
  • Discomfort with finger prick blood samples
  • Avoidance of almonds or chocolate
  • Temporomandibular joint disorder or oral cancer history
  • Recent dental or jaw surgery
  • Avoidance of hard foods for dental health
  • Use of dentures, braces, Invisalign, or dental implants causing chewing difficulty

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 3 visits over several weeks

Participants attend three separate visits to consume different types of white chocolate confectionery and provide blood samples. They will rate chewing experiences and feelings of satiety after eating each product.

3 visits (in-person)

Trial Site Locations

Total: 1 location

1

Department of Human Health Sciences

Guelph, Ontario, Canada, N1G 2G4

Actively Recruiting

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Research Team

A

Amanda J Wright, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

3

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