Comparing Monthly and Daily Vitamin D Treatments to Improve Vitamin D Blood Levels and Bone Health in Adults with Low Vitamin D

What this Trial Is About

Researchers are studying adults with hypovitaminosis D, a condition characterized by low vitamin D levels in the blood. This randomized clinical trial compares three different ways of taking vitamin D supplements to see how well they raise vitamin D levels and affect bone mineral density. The purpose is to find the best dosing method for improving vitamin D intake. Participants are assigned to one of three treatment groups Group A receives 0.266 mg of calcifediol once a month, Group B takes 25,000 IU of cholecalciferol every 15 days, and Group C uses 4 drops of calcifediol daily. Vitamin D blood levels are measured after one month of treatment to guide dosing. The study also monitors bone mineral density over an 18-month period. During the trial, participants have their vitamin D levels checked at one and six months after starting treatment. Bone density is assessed using DEXA scans between recruitment and 18 months. The study involves randomization and single masking to monitor and compare the effects of these vitamin D supplementation methods. Participation lasts up to 18 months, including follow-up assessments.

Cholecalciferol and Calcifediol Are Both Useful to Improve Vitamin D Serum Levels