Actively Recruiting
CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma Elasticum
Led by University Hospital, Angers · Updated on 2025-12-08
60
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study sets out to compare choriocapillaris flow deficits between healthy control subjects and patients with pseudoxanthoma elasticum. Pseudoxanthoma elasticum (PXE) is a rare, incurable hereditary disease caused by genetic mutations. The condition is characterised by excessive tissue mineralisation, which can result in a range of dermatological, vascular, and ophthalmological complications. Among these complications is the potential for visual impairment. The management of this condition is focused on the treatment of its complications. Degeneration of the retina and the choroid (the layer responsible for ensuring its vascularisation) occurs in the eye, resulting in premature degeneration. We would like to study the premature alteration of these structures, which could subsequently be used as an objective marker of the evolution of pseudoxanthoma elasticum.
CONDITIONS
Official Title
CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma Elasticum
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant without pseudoxanthoma elasticum and without eye disease
- Matched in age (+/- 5 years) and gender to a PXE patient in early disease stages
- Adult at time of inclusion
- Signed informed consent for participation
You will not qualify if you...
- Known eye diseases (maculopathy, glaucoma, optic neuropathy, retinopathy) of any cause
- Severe myopia worse than -6 diopters
- Diabetes
- Unable to complete required eye exams
- Pregnant, breastfeeding, or recently given birth
- Under psychiatric care with legal constraint
- Under legal protection
- Not covered by social security
- Eye disease found during study exam
- Unusable OCT angiography images even after pupil dilation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Angers University Hospital
Angers, France, 49000
Actively Recruiting
Research Team
L
Laurie MOUROZEAU, Doctor
CONTACT
M
Matthieu LE LAY, Master
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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