Actively Recruiting
Chronic Airway Disease and Multimorbidity Cohort: A Prospective Multicenter Observational Study on Exacerbations of COPD, Asthma, and Bronchiectasis
Led by China-Japan Friendship Hospital · Updated on 2025-02-17
2000
Participants Needed
9
Research Sites
N/A
Total Duration
On this page
Sponsors
C
China-Japan Friendship Hospital
Lead Sponsor
S
Second Affiliated Hospital of Xi'an Jiaotong University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how having multiple chronic conditions affects patients hospitalized due to flare-ups of chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis. This multicenter, observational study will follow at least 2,000 patients to better understand how these additional health issues influence hospital stay length, readmission rates, symptoms, lung function, quality of life, and healthcare use. Participants will be enrolled during their hospital stay for a CAD exacerbation, where detailed information such as medical history, lung tests, heart ultrasound, microbiology, imaging, and quality-of-life surveys will be collected. Blood and lung fluid samples will be taken for biomarker analysis. Patients will then be monitored closely over one year with follow-up visits at 1, 3, 6, 9, and 12 months to track disease progression, treatment adherence, exacerbations, and other health outcomes. Throughout the study, researchers will collect data on symptom scores, lung function tests, mental health, and healthcare costs. The main outcomes include hospital stay duration and rates of re-exacerbation within 12 months. Additional assessments include quality of life, mortality, imaging changes, medication use, and patterns of multiple medications. Data will be carefully managed and reviewed to ensure accuracy and contribute to improved care for CAD patients with multiple health conditions.
CONDITIONS
Brief Title
Chronic Airway Disease and Multimorbidity Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chronic obstructive pulmonary disease aged 40 years or older
- Patients with asthma or bronchiectasis aged 18 years or older
- Primary diagnosis on admission of acute exacerbation of COPD, uncontrolled asthma, or acute exacerbation of bronchiectasis
You will not qualify if you...
- Unable to undergo spirometry during the stabilization period
- Expected survival less than 1 month
- Refusal to sign informed consent
- Chest imaging showing new patchy infiltrating shadows, lobar or segmental solid shadows, ground glass shadows, or interstitial changes with or without pleural effusion
- Diagnosis of cystic fibrosis, interstitial lung disease, or other lung diseases with tractional bronchial dilation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during baseline hospitalization for eligibility assessment and informed consent
Duration - 3 to 30 days
During baseline hospitalization, clinical, laboratory, imaging, and quality-of-life assessments are conducted to understand disease severity and multimorbidity.
Hospital stay lasting 3 to 30 days
Duration - 12 months
Participants are followed for 12 months after discharge to record disease progression, treatment adherence, exacerbations, quality of life, and healthcare utilization.
Follow-up visits at 1, 3, 6, 9, and 12 months post-discharge
Trial Site Locations
Total: 9 locations
1
National Center for Respiratory Medicine, China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
2
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510280
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3
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450003
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4
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
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5
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
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6
The First Affiliated Hospital of China Medical University
Shenyang, Liaoning, China, 110001
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7
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710114
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8
Ruijin Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China, 200025
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9
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610041
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Research Team
K
Ke Huang, MD.
W
Wei Li, MD.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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