Actively Recruiting
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
Led by University of Colorado, Denver · Updated on 2024-10-10
100
Participants Needed
1
Research Sites
607 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
CONDITIONS
Official Title
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Daily or near daily cannabis use inhaled via joint, cigarette, or pipe with at least 20 joint years, confirmed by urine test
- Less than one pack year of tobacco use in lifetime, confirmed by urine test
- Ability to answer screening questions, provide informed consent, and contact information
- OR no cannabis use ever, confirmed by urine test (for control group)
- No tobacco use ever (for control group)
- Ability to answer screening questions, provide informed consent, and contact information (for control group)
You will not qualify if you...
- Cannabis use less than near daily or less than 20 joint years, or negative urine drug screen (for cannabis users)
- Tobacco use exceeding one pack year or positive urine cotinine screen
- High score on alcohol use disorder questionnaire (AUDIT-C)
- History of liver disease, heart attack, heart failure, end-stage kidney disease, or diabetes
- History of uncontrolled asthma or COPD
- History of HIV not controlled or on medication
- White blood cell count less than 3000
- Recent worsening of respiratory symptoms or low oxygen levels
- Use of systemic antibiotics in past 4 weeks
- Failure to provide assent
- Nutritional risk index below 95
- Age less than 21 or greater than 55
- Pregnancy
- Decision-making incapacity
- Prisoner status
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado, Denver
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
J
Jeffrey D McKeehan, MSN
CONTACT
E
Ellen L Burnham, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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