Study of Chronic Cannabis Smoking Effects on Lung Health, Oxidative Stress, and Immune Response in Adults Aged 18 to 55

What this Trial Is About

Researchers are studying the effects of chronic cannabis smoking on lung health, particularly focusing on lung function, pulmonary health, and the role of alveolar macrophages, which are immune cells in the lungs. This research addresses concerns that frequent cannabis use may increase oxidative stress in the lungs and impair immune responses, potentially raising the risk of respiratory infections. The study aims to fill gaps left by previous research, especially considering that modern cannabis contains higher THC levels than in past decades. The study compares two groups one consisting of adults aged 18 to 55 who have never used cannabis or tobacco, and another group of daily or near daily cannabis smokers with at least 20 joint years of use and minimal tobacco exposure. Participants will undergo procedures including bronchoscopy to collect lung cell samples, chest X-rays to check for lung diseases, and blood draws for analysis. These tests help researchers assess lung function, oxidative stress, and immune cell activity related to cannabis use. During the study, participants will be evaluated at baseline and at 18 hours for changes in alveolar macrophage function, including their ability to engulf harmful particles. Lung function tests and measures of oxidative stress in lung fluid collected by bronchoalveolar lavage will also be performed. The study includes detailed interviews to assess cannabis use patterns. Participants safety and health will be monitored throughout the research, which is expected to continue until July 2027.

Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response