Study of Liver Diseases Related to Alcohol Use and Metabolic Syndrome Including Patients With and Without Liver Cancer

What this Trial Is About

Researchers are investigating the metabolic factors, immune system elements, and imaging data linked to the development of Hepatocellular Carcinoma HCC in patients with liver disease caused by alcohol use or metabolic issues like Non-Alcoholic Steatohepatitis NASH. The study includes patients both with and without cirrhosis to better understand early molecular changes that may lead to HCC, especially in those without cirrhosis. This observational study involves patients categorized into four groups based on the presence of NAFLD or alcohol-related liver disease, and whether they have HCC. Participants will undergo clinical and biological assessments including dietary and physical activity questionnaires, liver function tests, and imaging studies. Liver biopsies and biological sample collections plasma, sera, DNA, leukocytes will be performed as part of routine care, with data collection spanning 10 years. Participants will be involved from as short as one day up to two months depending on biopsy timing. The study includes non-invasive and invasive assessments, liver imaging, and classification of liver cancer stages. Researchers will monitor various health parameters, collect biosamples for a biobank, and evaluate primary and secondary outcomes over a decade. This long-term follow-up aims to uncover mechanisms driving liver cancer development in these patient groups.

CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome