Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy, a Multicenter Prospective Randomized Double-blind Placebo-controlled Trial

What this Trial Is About

This research aims to evaluate whether taking 150 mg of aspirin daily before 20 weeks of pregnancy can help prevent complications in pregnant women with chronic hypertension. Chronic hypertension during pregnancy can lead to serious issues like preeclampsia, placental abruption, growth problems for the baby, early birth, and death of the mother or baby. Current guidelines recommend low-dose aspirin for some pregnant women at risk, but there is limited evidence specifically for those with chronic hypertension, so this study seeks to clarify its effectiveness. Participants will be randomly assigned to take either 150 mg of aspirin or a placebo once daily in the evening, starting before 20 weeks of pregnancy and continuing until about 36 weeks gestation. The study is double-blind, meaning neither the participants nor the researchers know who receives aspirin or placebo. Both groups will follow the same schedule, and treatment adherence is tracked with a daily log. During the study, participants will be monitored for maternal and baby health outcomes including preeclampsia, fetal growth, preterm birth, placental abruption, and any deaths. The trial also measures aspirins biological effects, side effects, and child development up to four years after birth. Study visits and assessments will occur throughout pregnancy and after delivery, with safety and treatment response carefully evaluated over time.

Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy