Actively Recruiting
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
Led by Centre Hospitalier Intercommunal Creteil · Updated on 2025-09-02
500
Participants Needed
20
Research Sites
467 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic hypertension.
CONDITIONS
Official Title
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women between 10 and 19 weeks plus 6 days of gestation
- Chronic hypertension diagnosed before pregnancy or before randomization, treated or untreated
- Singleton pregnancy
- Signed written informed consent
- Affiliated to social security
You will not qualify if you...
- Medical history requiring anticoagulation (e.g., antiphospholipid syndrome, deep vein thrombosis, pulmonary embolism, atherothrombosis, mechanical heart valves)
- Currently taking aspirin for reasons other than pregnancy
- Significant proteinuria (>300 mg/24 hours or proteinuria/creatininuria ratio ≥ 30 mg/mmol)
- Active bleeding
- History of severe preeclampsia with delivery before 34 weeks gestation
- Allergic to salicylates such as aspirin or NSAIDs
- Platelet count below 100,000 cells/microliter (within last 6 months)
- Bleeding disorders including hemophilia
- Any inherited or acquired hemorrhagic disease (including digestive hemorrhages, history of hemorrhagic stroke, thrombocytopenia)
- Positive for HIV, hepatitis B, or hepatitis C
- Participating in another interventional study affecting results
- Under 18 years old
- Under legal protection
- Psychiatric follow-up, poor understanding of French, or cognitive issues
- Duodenal ulcer
- Severe kidney failure
- Severe liver failure
- Severe heart failure
- Gout
- Known glucose-6-phosphate dehydrogenase deficiency
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 20 locations
1
CHU Bordeaux
Bordeaux, France
Actively Recruiting
2
CHU Caen
Caen, France, 14000
Withdrawn
3
CHU Antoine Béclère, AP-HP
Clamart, France
Actively Recruiting
4
Hôpital Louis Mourier, AP-HP
Colombes, France
Actively Recruiting
5
Centre Hospitalier Intercommunal de Créteil
Créteil, France, 94000
Actively Recruiting
6
CHU Dijon
Dijon, France
Actively Recruiting
7
CHU Bicêtre, AP-HP
Le Kremlin-Bicêtre, France
Actively Recruiting
8
CHRU Lille
Lille, France
Not Yet Recruiting
9
CHU Lyon
Lyon, France
Actively Recruiting
10
Hôpital St Joseph
Marseille, France
Withdrawn
11
CHRU Nancy
Nancy, France
Withdrawn
12
CHU Nantes
Nantes, France
Actively Recruiting
13
CHU Cochin- Port Royal, AP-HP
Paris, France
Actively Recruiting
14
CHU Robert Débré, AP-HP
Paris, France
Actively Recruiting
15
CHU Tenon
Paris, France
Actively Recruiting
16
Hôpital Trousseau, AP-HP
Paris, France
Actively Recruiting
17
CH Poissy
Poissy, France
Actively Recruiting
18
CHU St Etienne
Saint-Etienne, France
Actively Recruiting
19
CHU Toulouse
Toulouse, France
Not Yet Recruiting
20
CHU Tours
Tours, France
Withdrawn
Research Team
E
Edouard LE CARPENTIER
CONTACT
C
Camille JUNG
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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