Actively Recruiting
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Led by University of Alabama at Birmingham · Updated on 2026-04-09
74
Participants Needed
1
Research Sites
140 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes. The primary objective of this pilot study is to determine if anti-HTN treatment to BP\<130/80mmHg in pregnant patients with stage 1 HTN is associated with a difference in birthweight percentile at delivery. Patients with stage 1 hypertension in pregnancy will be randomized to BP goals of \<130/80mmHg or usual care to treatment only if BPs ≥140/90mmHg. For this pilot, the investigator will randomize a total of 74 eligible participants, 37 to active treatment to BP\<130/80mmHg and 37 to usual care.
CONDITIONS
Official Title
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Viable singleton gestation
- No fetal anomalies
- Blood pressures 130-139/80-89 mmHg on two occasions at least 4 hours apart prior to 20 weeks gestation
- Planning to deliver at UAB Hospital
- No indication for pregnancy termination
- Receiving care at the UAB prenatal clinics
You will not qualify if you...
- Declines randomization
- Known diagnosis of chronic hypertension with blood pressure ≥ 140/90 mmHg or current antihypertensive medication use
- Fetal demise diagnosed prior to enrollment
- Known major structural or chromosomal abnormalities prior to enrollment
- Contraindication to first line antihypertensive (Nifedipine or Labetalol)
- Comorbidities requiring blood pressure goals < 130/80 mmHg
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UAB
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
D
Donna Dunn, PhD
CONTACT
J
Jhana Plump
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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