Long-Term Effects of Aromatase Inhibitor Therapy on Heart and Brain Health in Breast Cancer Survivors

What this Trial Is About

Researchers are investigating the long-term effects of aromatase inhibitor therapy on heart and blood vessel health in women who have had hormone-positive breast cancer. This observational study compares breast cancer survivors at 1, 5, and 10 years after diagnosis with healthy women matched by age and body mass index. The study aims to understand how this therapy affects cardiovascular risk factors and brain health over time, as well as lifestyle factors and body composition. Participants include breast cancer survivors who received aromatase inhibitors as part of their usual care for up to 10 years post-diagnosis, along with matched healthy controls. The groups are categorized based on the time since diagnosis 1, 5, or 10 years. The study does not involve any new treatments but focuses on detailed health assessments to evaluate the impact of past endocrine therapy. During the study, participants will undergo several in-person sessions to measure heart and blood vessel function, including aortic stiffness, artery stiffness, blood pressure, and heart performance. They will also have tests for brain health, cognitive function, blood biomarkers like lipids and insulin resistance, and assessments of body composition and protein metabolism at home. Lifestyle factors such as diet, exercise, sleep, stress, and quality of life will be evaluated. The main outcome is aortic stiffness, with many secondary measures collected to understand cardiovascular and brain health comprehensively.

Chronic Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer