Effects of Daily Intake of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation A Randomized Crossover Study

What this Trial Is About

This clinical trial focuses on women aged 18 to 59 with functional constipation who do not consume enough dietary fiber. The study aims to understand whether adding dietary fibers can improve bowel movements and to compare the effects of two types of fibers fructooligosaccharide and psyllium. Researchers want to see if one fiber is more effective than the other while monitoring any side effects from fiber intake. Participants will consume 20 grams of fiber daily for six days, split into two doses of 10 grams each. The study uses a crossover design, where participants randomly start with either fiber A psyllium or fiber B fructooligosaccharide after an initial control period. Each fiber phase is followed by scintigraphic imaging to assess intestinal transit, with a seven-day washout period separating the two fiber treatments. During the trial, participants will keep daily records of their bowel habits and diet. Researchers will assess colonic transit time, gastric emptying, bowel function, quality of life, fecal microbiota, and short-chain fatty acids at various points. The study includes regular visits for imaging and data collection, with the entire process lasting several weeks. Safety and adherence will be closely monitored throughout the trial.

Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation: A Randomized Crossover Trial