Actively Recruiting
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain
Led by Eli Lilly and Company · Updated on 2026-03-27
150
Participants Needed
37
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to test the safety and efficacy of study drug LY4065967 for the treatment of diabetic peripheral neuropathic pain (DPNP). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292) which is a protocol to accelerate the development of new treatments for chronic pain.
CONDITIONS
Official Title
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have diabetic peripheral neuropathy affecting both lower legs for at least 6 months, diagnosed by a Michigan Neuropathy Screening Instrument score of 3 or higher
- Have a history and current diagnosis of type 1 or type 2 diabetes mellitus
- Have an HbA1c less than 11% and have been on a stable diabetes treatment regimen for at least 90 days before screening
- Have a body mass index of 40 kg/m2 or less at screening
You will not qualify if you...
- Are pregnant or breastfeeding
- Have other causes of pain that could affect self-assessment of diabetic peripheral neuropathic pain
- Have had a lower limb amputation related to diabetes, including the great toe
- Have low serum vitamin B12 levels (200 pg/mL or less)
- Have high blood pressure (systolic >140 mm Hg or diastolic >90 mm Hg) at screening
- Have a history or current significant heart disease, including arrhythmia, aortic aneurysm, heart failure, or electrolyte problems that increase arrhythmia risk according to the investigator's judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Central Research Associates
Birmingham, Alabama, United States, 35205
Actively Recruiting
2
Synexus Clinical Research US, Inc.
Phoenix, Arizona, United States, 85020
Actively Recruiting
3
Arizona Research Center
Phoenix, Arizona, United States, 85053
Actively Recruiting
4
Desert Oasis Healthcare Medical Group
Palm Springs, California, United States, 92262
Actively Recruiting
5
Artemis Institute for Clinical Research
Riverside, California, United States, 92503
Actively Recruiting
6
Artemis Institute for Clinical Research
San Diego, California, United States, 92123
Actively Recruiting
7
CMR of Greater New Haven
Hamden, Connecticut, United States, 06517
Actively Recruiting
8
Bradenton Research Center, Inc.
Bradenton, Florida, United States, 34205
Actively Recruiting
9
Accel Research Sites - DeLand Clinical Research Unit
DeLand, Florida, United States, 32720
Actively Recruiting
10
K2 MEDICAL Research THE VILLAGES
Lady Lake, Florida, United States, 32159
Actively Recruiting
11
K2 Medical Research ORLANDO
Maitland, Florida, United States, 32751
Actively Recruiting
12
Merritt Island Medical Research, LLC
Merritt Island, Florida, United States, 32952
Actively Recruiting
13
Suncoast Research Group
Miami, Florida, United States, 33135
Actively Recruiting
14
New Horizon Research Center
Miami, Florida, United States, 33165
Actively Recruiting
15
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States, 34652
Actively Recruiting
16
Renstar Medical Research
Ocala, Florida, United States, 34470
Actively Recruiting
17
Precision Clinical Research
Sunrise, Florida, United States, 33351
Actively Recruiting
18
Charter Research - Lady Lake
The Villages, Florida, United States, 32162
Actively Recruiting
19
Conquest Research
Winter Park, Florida, United States, 32789
Actively Recruiting
20
North Georgia Clinical Research
Woodstock, Georgia, United States, 30189
Actively Recruiting
21
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
22
DelRicht Research
New Orleans, Louisiana, United States, 70115
Actively Recruiting
23
Lucida Clinical Trials
New Bedford, Massachusetts, United States, 02740
Actively Recruiting
24
MedVadis Research Corporation
Waltham, Massachusetts, United States, 02451
Actively Recruiting
25
Great Lakes Research Group, Inc.
Bay City, Michigan, United States, 48706
Actively Recruiting
26
StudyMetrix Research
City of Saint Peters, Missouri, United States, 63303
Actively Recruiting
27
Clinvest Research LLC
Springfield, Missouri, United States, 65807
Actively Recruiting
28
Rochester Clinical Research, LLC
Rochester, New York, United States, 14609
Actively Recruiting
29
Lillestol Research
Fargo, North Dakota, United States, 58104
Actively Recruiting
30
META Medical Research Institute
Dayton, Ohio, United States, 45432
Actively Recruiting
31
DelRicht Research
Tulsa, Oklahoma, United States, 74133
Actively Recruiting
32
Altoona Center For Clinical Research
Duncansville, Pennsylvania, United States, 16635
Actively Recruiting
33
FutureSearch Trials of Neurology
Austin, Texas, United States, 78731
Actively Recruiting
34
Re:Cognition Health - Fort Worth
Fort Worth, Texas, United States, 76104
Actively Recruiting
35
Northwest Clinical Research Center
Bellevue, Washington, United States, 98007
Actively Recruiting
36
Rainier Clinical Research Center
Renton, Washington, United States, 98057
Actively Recruiting
37
Ponce Medical School Foundation Inc.
Ponce, Puerto Rico, 00716
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here