Daily Gamma Frequency Light and Sound Therapy for Mild Alzheimers Disease 6-Month Randomized Study With Optional 1-Year Extension

What this Trial Is About

Alzheimers disease AD causes significant memory loss and involves harmful protein buildups amyloid and tau in the brain, along with changes in brain wave patterns called gamma waves. Researchers found that stimulating these gamma waves at 40Hz using light and sound helped reduce these proteins and improved memory in mouse models. This study is investigating whether a similar light and sound device can safely stimulate the brains of people with mild AD to potentially improve brain function. Participants will be randomly assigned to use a device at home for 60 minutes daily over six months. Half will receive active stimulation at 40Hz, while the other half will receive a sham inactive version. The study includes three in-person visits for assessments at baseline, three months, and six months. Participants may continue in an extension phase for at least one year, receiving the active treatment and yearly follow-up visits. Throughout the study, participants will undergo brain wave EEG tests, MRI scans, blood and fecal sample collections, cognitive and memory tests, and complete questionnaires. A wearable device will track sleep and activity. Researchers will monitor changes in brain function, molecular markers, microbiome, cognition, and safety. The study aims to understand if this non-invasive therapy can be a potential treatment strategy for mild to moderate Alzheimers disease.

Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy