Actively Recruiting
Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics
Led by Florida International University · Updated on 2026-01-14
200
Participants Needed
1
Research Sites
245 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine if decreased production or release of endogenous opioid peptides by peripheral immune cells contributes to hypersensitivity in people with HIV
CONDITIONS
Official Title
Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed HIV diagnosis and currently a patient in the UAB 1917 HIV Clinic
- Age 19 to 65 years
- People living with HIV must be currently receiving stable antiretroviral therapy
- HIV-negative participants must be confirmed HIV negative
- HIV-negative participants with chronic widespread pain must report bodily pain more than once per week for at least three consecutive months
- HIV-negative participants without chronic pain must report no pain or pain less frequently than once per week for at least three consecutive months
You will not qualify if you...
- Anemia
- Current or past history of blood disorders that may increase hemolysis
- Active microbial infections affecting blood inflammatory cells
- Use of medications other than antiretroviral therapy that might interfere, except stable pain management drugs (excluding methadone or buprenorphine for opioid addiction)
- Systemic rheumatic diseases such as rheumatoid arthritis or lupus
- Cachexia (wasting syndrome) and severe frailty
- Clinically significant surgery within the past year
- Uncontrolled hypertension (SBP/DBP >150/95) or cardiovascular or peripheral arterial disease
- Poorly controlled diabetes (HbA1c > 8%)
- Neurological diseases like Parkinson's, multiple sclerosis, epilepsy
- Serious psychiatric disorder requiring hospitalization within past 12 months or active suicidal ideation
- Active suicidal risk at screening
- Cognitive impairment affecting understanding of study procedures
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ambulatory Care Center, Florida International University
Miami, Florida, United States, 33199
Actively Recruiting
Research Team
S
Saurabh Aggarwal, MD., PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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