Actively Recruiting
Chronobiology and Enteral Nutrition
Led by Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Updated on 2026-04-28
60
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Medical Nutritional Therapy (MNT) is critical for patients with impaired oral intake and is typically administered via enteral nutrition (EN). Current infusion practices-continuous 24-hour enteral nutrition for hospitalised patients-may induce circadian misalignment (chronodisruption). This misalignment can negatively impact metabolic function, sleep quality, and overall quality of life for both patients and caregivers. Synchronising MNT administration with circadian rhythms may improve metabolic balance, sleep, and patient well-being. Hypothesis: The timing of the administration of Medical Nutritional Therapy via continuous enteral nutrition (EN) in hospitalised patients may induce chronodisruption in biological rhythms (clock genes). This disruption can affect the metabolism of carbohydrates, lipids, and proteins, contributing to morbidity and altering chronotype, quality of life, and sleep patterns.
CONDITIONS
Official Title
Chronobiology and Enteral Nutrition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Use of enteral nutrition (EN) for 15 days or more
- Participants must be from the Regional University Hospital of Málaga, Virgen del Rocío Hospital of Seville, Reina Sofía University Hospital of Córdoba, or the NUPA Association
- No acute metabolic decompensation in the last 7 days
- Ability to answer questionnaires with or without family support
- Provided informed consent (patient or legal representative)
You will not qualify if you...
- Pregnancy
- Use of melatonin for sleep
- Uncontrolled psychiatric condition
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Regional Universitario de Málaga, FIMABIS
Málaga, Málaga, Spain, 29009
Actively Recruiting
Research Team
F
Francisca Rodríguez, PhD
CONTACT
G
Gabriel Olveira Fuster, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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