Actively Recruiting
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Led by The University of Texas Health Science Center, Houston · Updated on 2026-01-12
50
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation. Smoking and brain functional connectivity changes will be assessed at baseline, different stages of rTMS and/or follow-ups.
CONDITIONS
Official Title
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female between ages 22-65 years
- Ability to give written informed consent
- Smoking in the last one year or more and average cigarette per day 65 5 in the past 4 weeks
- Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above 10
- Currently under the care of a licensed primary care provider or mental healthcare provider
- Agrees to provide permission for communication between research and healthcare providers and contact information for two reliable persons 65 age 22 living within 30 minutes
You will not qualify if you...
- First-degree relative with inherited epilepsy, seizure disorder, or seizures or positive epilepsy screening questionnaire
- Smoking cessation treatment, clinical trial, or nicotine replacements within past 4 weeks
- Significant alcohol or other drug use (substance dependence within 6 months or substance abuse within 1 month) other than nicotine or marijuana dependence
- Major medical illnesses affecting brain function such as stroke, CNS infection or tumor, or other neurological conditions
- Taking more than 400 mg clozapine/day or failed TMS screening questionnaire
- Cardiac pacemakers, implanted medication pumps, intracardiac lines, acute unstable cardiac disease, or intracranial implants or metal objects near the head that cannot be safely removed
- History of head injury with loss of consciousness over 10 minutes or history of brain surgery
- Cannot refrain from alcohol, marijuana, or cigarette smoking at specified times prior to experiments
- Pregnant women or women of child-bearing potential without contraceptive use or recent unprotected sexual intercourse
- Moderate to high suicide risk per Columbia-Suicide Severity Rating Scale or investigator judgment
- Conditions increasing seizure risk such as sleep deprivation, major depressive disorder with dementia, underweight status, certain medication interactions, metabolic abnormalities, alcohol withdrawal, stimulant use, immunosuppressive therapy, dialysis, systemic infection, or fever
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center, Houston
Houston, Texas, United States, 77054
Actively Recruiting
Research Team
X
Xiaoming Du, PhD
CONTACT
V
Victoria Acosta
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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