Actively Recruiting
Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer
Led by Institut Pasteur · Updated on 2025-05-16
2500
Participants Needed
8
Research Sites
126 weeks
Total Duration
On this page
Sponsors
I
Institut Pasteur
Lead Sponsor
A
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control group. For this purpose: * Patients with pre-existing gastric lesions will be invited to participate to this study. If they are willing to participate an additional blood sample (9 mL) will be collected at the time of the blood collection performed during their routine care * Healthy subjects will be invited to participate to constitute the control group. If they are willing to participate a blood sample (9 ml) will be drawn specifically for this study
CONDITIONS
Official Title
Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or higher
- Written informed consent given before any study procedure
- Affiliated with a social insurance system
- Untreated glandular atrophy with or without intestinal metaplasia and/or dysplasia diagnosed by histology since 2014 (for patients with gastric lesions)
- Treatment-naïve gastric cancer (distal or proximal adenocarcinoma) (for patients with gastric lesions)
You will not qualify if you...
- Autoimmune disease or disease affecting the immune system (e.g., HIV)
- Chronic inflammatory disease
- Known active cancer other than gastric cancer
- Treated or currently treated within 3 months with therapy affecting the immune system (e.g., immunosuppressive therapy)
- Current long-term corticosteroid therapy
- Current long-term use of nonsteroidal anti-inflammatory drugs
- Pregnant or breastfeeding women
- Individuals under legal protection such as guardianship
- Participation in another clinical trial involving experimental medical products or devices
- Individuals currently in custody
- For healthy volunteers: history of Helicobacter pylori infection
- For healthy volunteers: history of gastric lesions including chronic gastritis, gastric atrophy, intestinal metaplasia, dysplasia, or cancer
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 8 locations
1
Ambroise Paré Teaching Hospital (AP-HP)
Boulogne-Billancourt, France
Completed
2
Beaujon Teaching Hospital (AP-HP)
Clichy, France
Actively Recruiting
3
Kremlin Bicêtre Teaching Hospital (AP-HP)
Le Kremlin-Bicêtre, France
Actively Recruiting
4
Cochin Teaching Hospital (AP-HP)
Paris, France
Actively Recruiting
5
INVOLvE - Investigation et volontaires en santé humaine (Institut Pasteur)
Paris, France
Actively Recruiting
6
Saint Antoine Teaching Hospital (AP-HP)
Paris, France
Actively Recruiting
7
Saint Antoine Teaching Hospital (AP-HP)
Paris, France
Not Yet Recruiting
8
Saint Louis Teaching Hospital (AP-HP)
Paris, France
Not Yet Recruiting
Research Team
E
Eliette TOUATI, PhD
CONTACT
O
Olivia CHENY, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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