Actively Recruiting
Circulating Biomarkers in the Development of Type 1 Diabetes
Led by City of Hope Medical Center · Updated on 2026-01-28
165
Participants Needed
1
Research Sites
219 weeks
Total Duration
On this page
Sponsors
C
City of Hope Medical Center
Lead Sponsor
I
Icahn School of Medicine at Mount Sinai
Collaborating Sponsor
AI-Summary
What this Trial Is About
More than 100 million U.S. adults are now living with diabetes or prediabetes. Investigators still do not fully understand how diabetes develops and how the disease worsens. Insulin is a hormone that helps the body use sugar as a fuel and control blood-sugar levels. People with diabetes have problems making insulin. This is because their insulin-producing beta cells -in the pancreas-are damaged or destroyed. A biomarker is a biological molecule (such as DNA, RNA (the genetic material of cells) or protein) that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker can be measured and found in blood and/or other body fluids (such as saliva and urine). Understanding the biology of beta cells could help find diabetes-related biomarkers. The discoveries from this research could help with early diagnosis of diabetes and lead to the creation of therapies for treating diabetes.
CONDITIONS
Official Title
Circulating Biomarkers in the Development of Type 1 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide documented informed consent or assent
- Have one of the following: type 1 diabetes (including children), adult type 2 diabetes, islet auto-antibody positive with HbA1c ≤ 5.6% (including children), adult with high blood sugar (HbA1c 5.7% to 6.4%), or adult control with HbA1c ≤ 5.6%
- Weigh at least 30 kg
- Willing to provide blood samples and allow medical record or lab result review if applicable
You will not qualify if you...
- Control subjects cannot have chronic conditions or history of cellular, tissue, or organ transplant
- Have sickle cell disease or untreated anemia (anemia treated and documented within 6 months is allowed)
- Have an active infection
- Have active cancer and are undergoing treatment
- Have had immunomodulatory therapy within 1 year before blood draw
- Type 1 diabetes patients receiving polyclonal regulatory T cell or dendritic cell therapy
- Have a bleeding disorder
- Women of childbearing potential who are pregnant or nursing (eligibility may be delayed per blood donation guidelines)
- Diabetic patients with conditions that could be harmed by blood removal of up to 100 mL
- Are employees supervised directly or indirectly by the study investigators
- Are a direct member of the study team
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
Research Team
S
Study Coordinator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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