Study of Blood Proteins Caspase-3 and Dystrophin in Adults With Acute Myocardial Infarction and Heart Failure

What this Trial Is About

Researchers are studying two proteins, cleaved caspase-3 and dystrophin, in the blood to see if their levels rise during acute myocardial infarction heart attack and if they are higher in those who develop heart failure afterward. These proteins are linked to heart muscle damage and may be detected using laboratory methods. The study aims to understand whether these markers can help identify people at risk of heart failure after a heart attack. The study observes men and women aged 18 and older who have had an acute myocardial infarction, with or without heart failure. A control group of men aged 60 and above without a history of heart attack or heart disease is also included. Researchers measure blood levels of the two proteins using laboratory tests. Heart failure diagnosis may involve imaging tests to assess heart function. The study does not involve interventions but monitors natural changes in these markers. Participants will be followed for up to three years to track hospitalizations for heart attack, stroke, or death. Researchers collect blood samples and clinical data to compare protein levels between those who develop heart failure and those who do not. The study includes monitoring heart function by imaging and clinical assessments. Participants health outcomes over time help determine the relationship between the proteins and heart disease progression.

Circulating Markers for Ischemic Heart Disease