Actively Recruiting
Circulating microRNAs and Response to Neoadjuvant Chemotherapy in Breast Cancer
Led by Atlas University · Updated on 2026-03-31
80
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective observational study aims to investigate subtype-specific circulating microRNAs (miRNAs) and their association with response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. Serum samples will be collected before NAC and prior to surgery, and changes in miRNA expression levels will be evaluated. Pathological complete response (pCR) and Miller-Payne scoring will be used to assess treatment response after NAC. The study also explores whether changes in circulating miRNA profiles can predict treatment response across different breast cancer subtypes. The findings may help identify biomarkers that support treatment planning and personalized therapy strategies.
CONDITIONS
Official Title
Circulating microRNAs and Response to Neoadjuvant Chemotherapy in Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed breast cancer
- Planned to receive neoadjuvant chemotherapy
- Biologically female
- Age 65 18 years
- Ability to provide informed consent
- Adequate organ function to receive standard NAC (based on routine clinical evaluation)
You will not qualify if you...
- Presence of metastatic disease at diagnosis
- Prior systemic chemotherapy for breast cancer
- Pregnancy or breastfeeding
- Active infection or uncontrolled comorbid conditions interfering with study participation
- Any condition preventing collection of blood samples
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Istanbul Atlas University Faculty of Medicine
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
E
Emine Yildirim, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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