Actively Recruiting
Circulating Tumor DNA (ctDNA) Monitoring in the Assessment and Prediction of the Efficacy of PARP Inhibitors (PARPi)
Led by Sun Yat-sen University · Updated on 2024-09-05
30
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the application value of customized ctDNA monitoring in efficacy assessment and prediction during PARPi treatment
CONDITIONS
Official Title
Circulating Tumor DNA (ctDNA) Monitoring in the Assessment and Prediction of the Efficacy of PARP Inhibitors (PARPi)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged 18 to 75 years
- Histologically or cytologically confirmed prostate adenocarcinoma with homologous recombination deficiency or DDR gene mutation
- Documented metastatic castration-resistant prostate cancer with planned PARP inhibitor treatment
- Measurable target lesion visible on imaging studies
- Available adequate tumor tissue sample collected before any treatment with specific quality criteria
- ECOG performance status of 0 to 1
- Estimated survival time of 12 weeks or more
- Willing and able to provide informed consent
You will not qualify if you...
- Currently receiving other anti-tumor therapies such as chemotherapy or immunotherapy
- Organ transplantation within the last 3 months
- Autoimmune diseases or history of HBV, HCV, or HIV infection (acute or chronic)
- Presence of pneumonia
- Severe concurrent illnesses or co-morbid conditions making participation unsuitable
- Unwilling or unable to provide informed consent
- Judged unsuitable for trial participation by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
Y
Yonghong Li, M.D.
CONTACT
J
Jun Wang, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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