Actively Recruiting
Circulating Tumor DNA (ctDNA) as a Predictive Biomarker for Immunotherapy in Advanced or Locally Advanced dMMR/MSI-H Colorectal Patients
Led by Geneplus-Beijing Co. Ltd. · Updated on 2025-09-04
60
Participants Needed
2
Research Sites
109 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
dMMR/MSI-H colorectal cancer patients are the dominant population of immunotherapy/neoadjuvant immunotherapy, but imaging evaluation of immunotherapy efficacy is insufficient. There are some cases, although no disease remission was found on imaging,pathological complete response (pCR) was confirmed after surgery. Meanwhile,previous studies have shown that dynamic changes in ctDNA can help assess immunotherapy efficacy. Therefore, we propose to conduct a multicenter, prospective, observational clinical study to explore the efficacy prediction and monitoring value of ctDNA in immunotherapy for advanced or locally advanced dMMR/MSI-H colorectal cancer.
CONDITIONS
Official Title
Circulating Tumor DNA (ctDNA) as a Predictive Biomarker for Immunotherapy in Advanced or Locally Advanced dMMR/MSI-H Colorectal Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Advanced or locally advanced dMMR/MSI-H colorectal cancer
- Expected to receive or currently receiving immune checkpoint inhibitor therapy
- ECOG performance score of 0 or 1
- Life expectancy of at least 12 weeks
You will not qualify if you...
- Presence of other untreated malignancies
- Serious systemic diseases that impair ability to complete the study
- Autoimmune disease unsuitable for PD1 monoclonal antibody therapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
2
Fudan University Shanghai Cancer Center
Shanghai, China
Actively Recruiting
Research Team
X
Xiaoyan Zhou, PhD
CONTACT
J
Junjie Peng, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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