Actively Recruiting
Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer
Led by Zealand University Hospital · Updated on 2026-01-09
350
Participants Needed
5
Research Sites
461 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is a prospective randomized interventional study including patients with advanced non-small cell lung cancer, receiving immunotherapy, with the aim of optimizing treatment monitoring. The study aims to investigate the clinical utility of liquid biopsy monitoring in order to reduce the numbers of inefficient treatments and needless toxicity - and to explore the cost-effectiveness and cost-utility of introducing liquid biopsy monitoring in daily clinical practice.
CONDITIONS
Official Title
Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly diagnosed, histologically verified Non-Small Cell Lung Cancer (NSCLC)
- Advanced or locally advanced disease without curative treatment options
- Age over 18 years
- Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0-1
- Measurable disease according to iRECIST criteria version 1.1
- Eligible for first-line immunotherapy monotherapy
- Signed informed consent
You will not qualify if you...
- Presence of targetable alterations in EGFR, ALK, or ROS-1
- Having other active cancers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
Department of Clinical Oncology
Hillerød, Region H, Denmark
Actively Recruiting
2
Department of Clinical Oncology and Palliative Care
Næstved, Region Sjælland, Denmark
Actively Recruiting
3
Department of Clinical Oncology and Palliative Care
Roskilde, Region Sjælland, Denmark
Actively Recruiting
4
Department of Oncology
Aalborg, Denmark
Not Yet Recruiting
5
Department of Oncology
Vejle, Denmark
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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