Actively Recruiting
Circulating Tumor DNA in Primary Mediastinal Large B-cell Lymphoma (PMBL)
Led by Centre Henri Becquerel · Updated on 2021-04-01
87
Participants Needed
2
Research Sites
362 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare the predictive value in terms of specificity of circulating tumor DNA (ctDNA) and positron emission computed tomography (PET-CT) after 2 cycles of chemotherapy (C2), on the probability of obtaining a metabolic complete response after 4 cycles of induction chemotherapy (C4) in patients with primary mediastinal large B cell lymphoma (PMBL) receiving standard R-CHOP14 or R-ACVBP.
CONDITIONS
Official Title
Circulating Tumor DNA in Primary Mediastinal Large B-cell Lymphoma (PMBL)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient over 18 years of age
- Newly diagnosed with diffuse primary B lymphoma of the mediastinum confirmed by biopsy according to WHO 2016 classification
- Any disease stage (I-IV)
- Any International Prognostic Index (IPI) score (0-5)
- Mediastinal involvement present
- Untreated except emergency corticosteroid therapy less than 2mg/kg/day for 7 days
- Planned treatment with R-CHOP-14 or R-ACVBP using PET-CT guided strategy
- Tumor uptake above liver background on pre-treatment FDG PET/CT with Deauville score 4 or higher
- Signed informed consent before any study procedures
- Affiliated with or beneficiary of a social protection plan
You will not qualify if you...
- Already started chemotherapy treatment
- Contraindication to FDG PET-CT
- No mediastinal involvement
- Positive HIV serology
- Positive hepatitis B or C serology with positive viral load
- Under guardianship or curatorship
- Pregnant or breastfeeding
- Unable to understand the study or comply with study requirements due to language, psychological, or geographical reasons
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Centre Hospitalier Lyon Sud
Lyon, France
Not Yet Recruiting
2
Centre Henri Becquerel
Rouen, France
Actively Recruiting
Research Team
V
VINCENT CAMUS, MD
CONTACT
R
RICHARD DORIANE, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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