Actively Recruiting
CirrhoCare- Using Smart-phone Technology to Enhance Care and Access to Treatment for Cirrhosis
Led by University College, London · Updated on 2026-05-07
214
Participants Needed
15
Research Sites
166 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
C
CyberLiver Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
The CirrhoCare trial is a multi-centre, open label randomised controlled trial in patients with decompensated cirrhosis. The trial aims to investigate the clinical and cost-effectiveness of CirrhoCare digital home monitoring and management with current standard of care in these patients.
CONDITIONS
Official Title
CirrhoCare- Using Smart-phone Technology to Enhance Care and Access to Treatment for Cirrhosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older diagnosed with cirrhosis of any cause
- Cirrhosis confirmed by standard clinical criteria, ultrasound, or biopsy
- If cirrhosis is due to autoimmune hepatitis, stable corticosteroid use for at least 3 months prior
- Cirrhosis severity score (CLIF-C AD) between 42 and 65 at screening
- Hospitalization for acute decompensation including ascites, variceal bleeding, hepatic encephalopathy, bacterial peritonitis, or hepatorenal syndrome
- Ability to provide informed consent
You will not qualify if you...
- Acute-on-chronic liver failure grade 2 or higher
- CLIF-C AD score 66 or above indicating high mortality risk
- Current overt hepatic encephalopathy grade II-IV preventing consent
- Active liver cancer or recent remission less than 6 months for single tumor or less than 12 months for multiple tumors within Milan criteria
- Significant other serious diseases with poor short-term prognosis such as severe heart failure, advanced lung disease, or severe kidney disease
- Refractory ascites on palliative care pathway
- Listed for liver transplant
- Current active cancers outside the liver
- Mental incapacity or language barriers preventing study participation
- Active viral infections not yet fully treated
- Severe frailty, addiction history with recent relapses
- Other reasons deemed unsuitable by the investigator including end-of-life care
- Participation in other interventional clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom, B15 2GW
Actively Recruiting
2
Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust
Brighton, United Kingdom, BN2 5BE
Actively Recruiting
3
Walsgrave General Hospital, University Hospital Coventry & Warwickshire NHS Trust
Coventry, United Kingdom, CV2 2DX
Actively Recruiting
4
Royal Liverpool University Hospital, Liverpool University Hospitals NHS Foundation Trust
Liverpool, United Kingdom, L7 8YE
Actively Recruiting
5
The Royal London Hospital, Barts Health NHS Trust
London, United Kingdom, E1 1FR
Actively Recruiting
6
Whittington Hospital, Whittington Health NHS Trust
London, United Kingdom, N19 5NF
Actively Recruiting
7
Royal Free Hospital, Royal Free London NHS Foundation Trust
London, United Kingdom, NW3 2QG
Actively Recruiting
8
St Thomas Hospital, Liverpool University Hospitals NHS Foundation Trust
London, United Kingdom, SE1 7EH
Not Yet Recruiting
9
King's College Hospital, King's College Hospital NHS Foundation Trust
London, United Kingdom, SE5 9RS
Actively Recruiting
10
St George's Hospital, St George's university Hospital NHS Foundation Trust
London, United Kingdom, SW17 0QT
Actively Recruiting
11
Queen's Medical Centre, Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom, NG7 2UH
Actively Recruiting
12
John Radcliff Hospital, Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom, OX3 9DU
Actively Recruiting
13
Derriford Hospital, University Hospitals Plymouth NHS Trust
Plymouth, United Kingdom, PL6 8DH
Actively Recruiting
14
Southampton General Hospital, University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
15
Torbay Hospital, Torbay and South Devon NHS Foundation Trust
Torquay, United Kingdom, TQ2 7AA
Actively Recruiting
Research Team
T
Tasheeka Jeyapalan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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