Cirrhosis Care Alberta CCAB Improving Care and Reducing Hospital Use for Adults with Liver Cirrhosis Using a Standardized Order Set
Led by University of Alberta · Updated on 2025-08-21
3975
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Liver cirrhosis causes serious health problems and early death for many patients with digestive diseases. There are gaps in care that lead to high hospital readmission rates and lower quality care. The Cirrhosis Care Alberta CCAB program is a three-year quality improvement effort designed to enhance care quality, reduce hospital use, and meet the needs of both patients and healthcare providers across Alberta by addressing multiple factors that contribute to hospital stays and readmissions.
The CCAB intervention includes a comprehensive care bundle with admission and discharge order sets focusing on managing cirrhosis complications, frailty, malnutrition, alcohol use disorder, and community transition. It also offers patient and caregiver education to improve self-management and supports provider education for nurses and physicians on cirrhosis care and alcohol use treatments. Additionally, community care pathways target common complications like hepatic encephalopathy and ascites to provide timely support and reduce emergency visits.
Participants will be involved throughout the three-year study with assessments of hospital length of stay and readmission rates, emergency and outpatient visits, survival, disease severity, and how well the intervention is implemented. These outcomes will be measured at baseline and over one to two years to evaluate the programs impact. The study uses non-randomized groups including usual care and intervention with or without electronic medical record integration.
CONDITIONS
Brief Title
Cirrhosis Care Alberta (CCAB): A Pragmatic Type II Hybrid Effectiveness Implementation Trial
Research Team
P
Puneeta Tandon, MD
M
Michelle Carbonneau, MN, NP
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match. Sign up to get personalized trial recommendations delivered to your inbox.
Adults greater than 18 years of age with a clinical diagnosis of cirrhosis confirmed by compatible radiology, histology, or fibroscan
Admitted to a study hospital site
You will not qualify if you...
Adult patients who do not have cirrhosis
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Up to 3 years
Participants receive care guided by a standardized cirrhosis order set aimed at improving management of cirrhosis complications, frailty, malnutrition, alcohol use disorder, and transitions to community care.
Visits occur as part of routine hospital admissions and follow-up care
Long-term Monitoring
Duration - Up to 3 years
Participants are observed for outcomes such as hospital readmission, length of stay, emergency department visits, outpatient visits, and survival throughout the study period.
Ongoing monitoring during and after intervention
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
3
Similar Trials
Using 3D Magnetic Resonance Elastography to Assess Cirrhosis, Advanced Chronic Liver Disease, and Portal Hypertension
A Prospective Multicenter Study to Develop a Non-Invasive Risk Stratification Method
Safety Study of Siplizumab as Induction Therapy in Adults With Autoimmune Liver Diseases Undergoing Liver Transplant
Study of Simvastatin Plus Carvedilol Versus Carvedilol Alone in Adults With Cirrhosis and Cirrhotic Cardiomyopathy to Improve Heart Function and Reduce Liver Complications and Death
Study of Changes in Bile Acid Profile and Gut Microbiota in Adults Treated with Bulevirtide for Hepatitis Delta Virus Infection
Study of Glucose Changes Around Liver Transplant in Adults with Cirrhosis
Tracking Diabetes Risk Using Glucose Monitors and Other Tests
Study of Liver Diseases Related to Alcohol Use and Metabolic Syndrome
Including Patients With and Without Liver Cancer
Cirrhosis Care Alberta CCAB Improving Care and Reducing Hospital Use for Adults with Liver Cirrhosis Using a Standardized Order Set
Registry Study of Adults Hospitalized with Liver Cirrhosis at F.D. Roosevelt Teaching Hospital
Study of Cirrhotic Cardiomyopathy in Critically Ill Patients Using Echocardiography, Biomarkers, and Heart Tissue Analysis
Study Comparing Two-Dose and Three-Dose Heplisav-B Vaccine Schedules in Adults With Cirrhosis or Chronic Liver Disease
Have more questions? Get in touch with our team for quick support
Published Research Related To This Trial
The cirrhosis care Alberta (CCAB) protocol: implementing an evidence-based best practice order set for the management of liver cirrhosis - a hybrid type I effectiveness-implementation trial.