Pragmatic Randomized Trial Evaluating CirrhosisRx Clinical Decision Support System on Guideline Adherence and Outcomes for Patients With Cirrhosis

What this Trial Is About

Researchers are evaluating the impact of CirrhosisRx, a new clinical decision support (CDS) system, compared to usual care for hospitalized patients with cirrhosis. The study aims to improve adherence to national quality measures and clinical outcomes, addressing the high rates of hospital readmission and mortality among cirrhosis patients. This pragmatic randomized controlled trial uses stepped-wedge cluster randomization of treatment teams to assess the system's effectiveness. Participants receive care either with access to CirrhosisRx, which organizes clinical data and links it to guideline-based order sets for cirrhosis, or with usual care without this system. The trial involves inpatient settings where providers will use or not use the CDS system as assigned. The study focuses on inpatient cirrhosis care and compares groups over time under routine hospital conditions. Throughout approximately 7 days of hospitalization, researchers will monitor adherence to quality measures and clinical outcomes such as inpatient mortality. Data collection includes tracking how well providers follow national guidelines and patient health status during the hospital stay. The study is led by the University of California, San Francisco and follows patients from admission through their hospital course to assess the impact of the CDS system on care quality and outcomes.

CirrhosisRx CDS System