Actively Recruiting
Cisplatin-based and Carboplatin-based Chemoradiation in Locoregionally Advanced Nasopharyngeal Carcinoma
Led by Nanfang Hospital, Southern Medical University · Updated on 2023-06-18
482
Participants Needed
1
Research Sites
465 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare cisplatin-based with carboplatin-based chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma (NPC), in order to confirm the value of carboplatin-based chemoradiotherapy in NPC patients.
CONDITIONS
Official Title
Cisplatin-based and Carboplatin-based Chemoradiation in Locoregionally Advanced Nasopharyngeal Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with newly confirmed non-keratinizing nasopharyngeal carcinoma
- Tumor staged as T3-4Nx or TxN2-3 without distant metastasis (M0)
- Karnofsky performance score greater than 70
- Adequate blood counts: leucocytes 4000/bcL, hemoglobin 90 g/L, platelets 100000/bcL
- Normal liver function: ALT and AST less than 1.5 times upper limit of normal, ALP less than 2.5 times upper limit, bilirubin within normal limits
- Adequate kidney function with creatinine clearance 60 ml/min
- Provided written informed consent after being informed about the study
You will not qualify if you...
- Keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma
- Age under 18 or 65 years and older
- Treatment with palliative intent
- Prior malignancy except treated basal cell or squamous cell skin cancer, or in situ cervical cancer
- Pregnant or breastfeeding
- Previous radiotherapy except for non-melanoma skin cancers outside the treatment area
- Prior chemotherapy or surgery (except diagnostic) to primary tumor or lymph nodes
- Severe other diseases causing high risk or poor compliance, such as unstable cardiac disease, renal disease, chronic hepatitis, poorly controlled diabetes, or emotional disorders
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Southern medical university
Guangzhou, Guangdong, China, 510515
Actively Recruiting
Research Team
J
Jian Guan, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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