Actively Recruiting
Cisplatin to Patients With Pancreatic Cancer and Homologous Recombination Deficiency
Led by Fudan University · Updated on 2025-08-07
30
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy of cisplatin based regimen to patients with advanced pancreatic cancer and homologous recombination deficiency.
CONDITIONS
Official Title
Cisplatin to Patients With Pancreatic Cancer and Homologous Recombination Deficiency
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willingness and ability to sign informed consent
- Age 18 to 80 years
- ECOG performance status between 0 and 2
- Histological or cytological confirmation of advanced pancreatic adenocarcinoma
- Tumor progression after at least one chemotherapy treatment
- Confirmed homologous recombination deficiency by genetic or molecular testing
- At least one measurable tumor lesion according to RECIST criteria
- Expected survival of at least 3 months
- Adequate organ function shown by laboratory tests
- Agreement to use effective contraception if of childbearing potential
You will not qualify if you...
- Pregnant or nursing women
- Patients with primary pancreatic cancer
- Previous treatment with platinum drugs or PARP inhibitors
- Pancreatic cancer not confirmed as adenocarcinoma by pathology
- Active digestive tract inflammation such as pancreatitis or cholecystitis
- Severe uncontrolled diseases that could interfere with study compliance or results
- Renal insufficiency or need for dialysis
- Other serious illnesses that could affect treatment safety
- Allergy to cisplatin or other platinum drugs
- Unwillingness or inability to follow study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Cancer Center
Shanghai, China
Actively Recruiting
Research Team
Y
Ying Yang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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