Actively Recruiting
Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis
Led by Marmara University · Updated on 2026-04-02
75
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Multiple sclerosis (MS) is a chronic neurological disease that often involves spasticity, leading to difficulties in movement and lower quality of life. This study aims to classify spasticity patterns in the upper and lower limbs of adults with MS and to explore how these patterns relate to their quality of life. The study is designed as a prospective cross-sectional observational research to better understand these spasticity patterns and their impact on patients' daily function. Adult patients with MS and clinical spasticity will participate in a single study visit where spasticity will be assessed using the Modified Ashworth Scale and limb posture evaluations. Functional performance will be measured with the Timed 25-Foot Walk Test for lower limbs and the 9-Hole Peg Test for upper limbs. The study will also evaluate the impact of spasticity on quality of life using the Patient-Reported Impact of Spasticity Measure (PRISM). During the visit, demographic and clinical data will be collected, including disease duration, subtype, and previous treatments. Researchers will record spasticity severity and patterns in different joints of the upper and lower extremities. Functional ability and disability levels will be assessed, and participants will complete questionnaires about how spasticity affects their daily life and psychosocial well-being. The results aim to provide detailed descriptions of spasticity in MS to improve individualized rehabilitation and treatment planning.
CONDITIONS
Brief Title
Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of multiple sclerosis according to the 2024 McDonald criteria
- Age 18 years or older
- Presence of clinical spasticity with Modified Ashworth Scale score of 1 or higher in at least one joint
- Ability to understand study procedures and provide informed consent
- No significant cognitive impairment
You will not qualify if you...
- Presence of orthopedic, rheumatologic, or neurological conditions affecting movement other than multiple sclerosis
- Botulinum toxin type A injection within the previous 3 months
- Previous surgical treatment for upper extremity spasticity
- Bone deformities affecting the upper extremity
- Inability or unwillingness to provide informed consent
- Presence of cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a comprehensive clinical assessment of upper and lower limb spasticity patterns, functional performance tests, and patient-reported outcome measures during a single study visit.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Marmara Üniversitesi Tıp Fakültesi, Istanbul, Maltepe 34854
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
F
Fatma Saika Kahvecioglu Atabay
E
Evrim Karadag Saygi
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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