Study of Laparoscopic Renal Artery Nerve Blockade Surgery for Lowering Blood Pressure in Patients with Retroperitoneal Disease and Hypertension

What this Trial Is About

Researchers are evaluating the effectiveness and safety of laparoscopic renal artery perivascular nerve blockade surgery for patients who have retroperitoneal diseases and hypertension. The study aims to find out if this nerve blockade can reduce blood pressure after surgery and lessen the need for blood pressure medications. It also aims to assess the safety of the procedure and whether it causes any complications. Participants will be randomly assigned to one of two groups. One group will receive surgery related to their primary disease along with the nerve blockade procedure, while the other group will only have the surgery related to their primary disease, such as laparoscopic partial nephrectomy or adrenalectomy. The nerve blockade involves carefully dissecting the renal artery to separate nerve tissue within specific measurements, ensuring surgical safety. During the study, patients will keep their antihypertensive medication unchanged for three months following surgery. After this period, they will have a 24-hour ambulatory blood pressure monitoring visit at the hospital. Researchers will measure blood pressure at three months post-surgery as the primary outcome. Secondary outcomes include blood pressure at other time points, medication use, health status, and pain scores, assessed up to two years after surgery.

Clinical Analysis of the Antihypertensive Effect of Laparoscopic Peripheral Nerve Blockade of the Renal Artery in Patients With Retroperitoneal Disease and Hypertension