Actively Recruiting
Clinical Analysis of the Antihypertensive Effect of Laparoscopic Peripheral Nerve Blockade of the Renal Artery in Patients With Retroperitoneal Disease and Hypertension
Led by Ruijin Hospital · Updated on 2025-02-17
246
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to evaluate the efficacy and safety of laparoscopic renal artery nerve blockade surgery in patients with retroperitoneal diseases complicated by hypertension. The study aims to address the following two questions: 1. Can laparoscopic renal artery perivascular nerve blockade reduce postoperative blood pressure and decrease the dependence on antihypertensive medications in patients with retroperitoneal diseases and hypertension? 2. What is the safety profile of the procedure, and does it lead to any complications? The researchers will randomly assign patients to the experimental group and the control group. The experimental group will undergo surgery related to the primary disease in addition to laparoscopic renal artery perivascular nerve blockade, while the control group will only receive surgery related to the primary disease. This design allows for a comparison of the effects of renal artery perivascular nerve blockade on postoperative blood pressure. Participants will: 1. Patients will undergo either surgery related to the primary disease combined with renal artery perivascular nerve blockade, or surgery related to the primary disease alone. 2. For the three months following surgery, the antihypertensive medication regimen will remain unchanged from the preoperative plan. At the end of the three-month period, patients will visit the hospital for 24-hour ambulatory blood pressure monitoring.
CONDITIONS
Official Title
Clinical Analysis of the Antihypertensive Effect of Laparoscopic Peripheral Nerve Blockade of the Renal Artery in Patients With Retroperitoneal Disease and Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Renal artery diameter 4 mm or larger and length at least 20 mm
- Age between 18 and 75 years, any gender
- Scheduled for laparoscopic surgery for adrenal tumor, early kidney cancer, kidney cyst, or related conditions
- Diagnosed with hypertension confirmed by blood pressure measurements or current use of antihypertensive medication for at least 4 weeks
- Estimated glomerular filtration rate (eGFR) of 45 ml/min/1.73 m² or higher
- Willing and able to follow study protocol, give written informed consent, and participate in follow-up visits
You will not qualify if you...
- Renal artery abnormalities such as 50% or greater narrowing or prior balloon angioplasty or stent placement
- Recent cardiovascular events in past 6 months including heart attack, unstable angina, or stroke
- Extensive atherosclerosis with thrombosis or unstable plaques
- Significant heart valve disease causing major blood flow changes
- Prior similar surgeries like renal sympathetic nerve ablation by catheter
- Other severe organic diseases
- Participation in other clinical trials
- Investigator's judgment deeming patient unsuitable for the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ruijin hospital
Shanghai, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here