Actively Recruiting
Clinical Application of ctDNA Dynamic Monitoring in Neoadjuvant Therapy for HER2-positive Breast Cancer Patients
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2024-07-24
50
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. To explore the predictive value of ctDNA in HER2 positive breast cancer neoadjuvant therapy population; 2. To evaluate the prognostic value of ctDNA in HER2 positive breast cancer neoadjuvant therapy population.
CONDITIONS
Official Title
Clinical Application of ctDNA Dynamic Monitoring in Neoadjuvant Therapy for HER2-positive Breast Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 75 years with clinically and pathologically diagnosed breast cancer
- ECOG performance score of 0 to 1
- Histologically confirmed early or locally advanced invasive breast cancer with tumor size over 2 cm and HER2 positive by IHC or FISH
- No prior treatment for breast cancer before enrollment
- Measurable lesions according to RECIST 1.1 standards
- Voluntary participation with signed informed consent and good compliance
- Planning to receive neoadjuvant therapy for breast cancer
You will not qualify if you...
- Known metastatic or stage IV breast cancer
- Presence of other untreated malignant tumors besides breast cancer
- Serious systemic diseases that may impair ability to complete the study
- Other serious illnesses or conditions that could cause early study termination, including mental illness, severe lab abnormalities, or family/social factors
- Inability to follow the clinical follow-up schedule
- Inability to undergo or provide required efficacy evaluations such as CT scans
- Insufficient tumor tissue or peripheral blood samples for analysis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
Actively Recruiting
Research Team
Z
Zhihone Zhang, Doctor of Medicine
CONTACT
J
Jing Wu, Doctor of Medicine
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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