Actively Recruiting
Clinical Sequencing Project for Early Gastric Cancer and Precancerous Gastric Adenoma Patients for Personalized Cancer Clinic
Led by Samsung Medical Center · Updated on 2025-09-12
1730
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying early gastric cancer and precancerous gastric adenoma to improve diagnosis and predict recurrence. These conditions have a high cure rate when detected early, often treatable by endoscopic removal, which helps maintain a good quality of life. However, there are currently no markers available to diagnose early gastric cancer or predict its return after treatment. The study collects tumor tissue and blood samples from patients diagnosed with early gastric cancer or gastric adenoma at different times: initially, 2 months, 1 year after treatment, and if recurrence occurs. Advanced genetic testing methods, including targeted sequencing and copy number variation analysis, are used to profile tumors. Additional tests include immunohistochemistry and cancer-specific scans to analyze molecular changes. Participants will undergo sample collection and molecular profiling over up to 2 years to identify biomarkers that help diagnose and predict cancer recurrence. Researchers will review genetic changes over time and measure disease-free survival. The goal is to gather detailed molecular information to support personalized care for these patients.
CONDITIONS
Brief Title
Clinical Application of Genetic Sequencing of Early Gastric Cancer and Gastric Adenoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 19 years or older
- Histologically confirmed diagnosis of early gastric cancer or precancerous gastric adenoma
- Availability of excess tissue from previous biopsy or endoscopic treatment for research
- Life expectancy greater than 3 months
- Voluntary consent to participate in the clinical trial
You will not qualify if you...
- Insufficient sample quantity for analysis
- Considered unsuitable for the study by the researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At initial treatment
Participants provide tumor tissue and blood samples for genomic examination and molecular profiling at the time of initial treatment.
1 baseline visit (in-person)
Duration - Up to 2 years or until recurrence
Participants provide additional tissue and blood samples at 2 months, 1 year after treatment, and at recurrence to observe changes in tumor molecular profile and to identify biomarkers for diagnosis and prognosis.
3 follow-up visits (in-person) at 2 months, 1 year, and at recurrence if applicable
Trial Site Locations
Total: 1 location
1
Samsung medical center
Seoul, South Korea
Actively Recruiting
Research Team
C
Clinical Research Coordinator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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