Evaluating the J-PET Scanner Prototype Using Plastic Scintillators for PET Imaging Assessing Positronium Biomarker and Three-Photon Imaging in Whole-Body PET Scans

What this Trial Is About

This research investigates the clinical use of a new type of positron emission tomography PET scanner called the J-PET, which uses plastic scintillators instead of expensive crystal detectors. This advanced imaging technique aims to detect biochemical changes in tissues by measuring positron annihilation events and the lifetime of ortho-positronium atoms, potentially providing a novel diagnostic biomarker. The study explores whether this technology can offer accurate PET imaging with lower costs and increased availability compared to conventional PET scanners. Participants referred for routine PETCT scans of the brain or whole body will undergo an additional J-PET scan using the prototype scanner with plastic scintillators. This diagnostic test records radiation distribution and positronium lifetimes over approximately 20 minutes, following administration of standard radiopharmaceuticals such as 18FFDG, 68GaGa-PSMA, 18Fcholine, or 68GaGa-DOTATATE. The J-PET scanners modular design and unique detection capabilities enable three-photon imaging and the study of positronium as a biomarker. During the study, researchers will compare images and diagnostic data from the J-PET scans with conventional PET results. They will assess image quality, subjective evaluation, agreement between methods, and diagnostic accuracy over several months. The primary measure is the consistency of findings within 12 weeks. Participants will undergo these evaluations without extra risk beyond their standard PETCT scan, and data will be collected to determine the feasibility and potential clinical benefits of J-PET technology.

Clinical Application of the J-PET Scanner Prototype