Actively Recruiting
Clinical Applications of Advanced Ophthalmic Imaging
Led by University of Miami · Updated on 2025-08-12
5000
Participants Needed
1
Research Sites
1200 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The first phase is an observational phase which studies the eye in various conditions. The second phase is an interventional phase which studies the changes in the eyes after taking an over-the-counter medical food (Ocufolin) for 6 months.
CONDITIONS
Official Title
Clinical Applications of Advanced Ophthalmic Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Self-reported normal healthy subjects
- Clinical diagnosis of Alzheimer's disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetes, or stroke
- Ability to keep the eye open for imaging
- At least 18 years old with full legal capacity to consent
- Read and signed informed consent
- Willing and able to follow study instructions
- Clear corneas and crystalline lens
- Initial visual acuity of 20/80 or better
- MTHFR C677TT homozygous or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurysmal vascular retinopathy
- Hemoglobin A1c of 10 or less
- Normotensive with or without medications
- No retinal capillary dropout or macular edema
- Blood homocysteine level greater than 9
You will not qualify if you...
- Unable to read and sign the informed consent form
- Unable to receive ophthalmic imaging
- Unable to tolerate bright light during imaging
- Active ocular disease
- Eye surgery or eye injury within the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bascom Palmer Eye Institute
Miami, Florida, United States, 33136
Actively Recruiting
Research Team
J
Jianhua Wang, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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