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Personalized Cell-Based Testing to Predict Treatment Response in Autoimmune and Autoinflammatory Rheumatic Diseases Including Rheumatoid Arthritis, Psoriatic Arthritis, and Vasculitis Observational Study Using Patient Blood Samples
Led by University of Bonn · Updated on 2025-09-02
120
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are exploring a new way to personalize treatment for autoimmune and autoinflammatory rheumatic diseases. This study aims to develop and use a special cell-based test that helps predict how well patients will respond to disease-modifying antirheumatic drugs DMARDs. By identifying the best treatment for each person, the study hopes to improve treatment success, shorten the time to see benefits, and lower healthcare costs. The approach focuses on analyzing immune cells from patients to better understand their response to different therapies. The study includes several groups newly diagnosed patients without prior treatment, patients already on immunomodulatory therapy, and healthy individuals for comparison. Blood samples are collected at different times depending on the group. Researchers use advanced laboratory methods to test immune cell responses to DMARDs outside the body, measuring specific immune signals and gene activity. Archived tissue samples are also studied to link immune profiles with disease features. This design allows detailed analysis of immune function related to treatment. Participants will provide blood samples and undergo clinical assessments over time, including baseline and follow-up visits at 6 and 12 weeks, with additional optional visits if disease worsens or treatment changes. The study measures changes in immune cell types and activity using the ex vivo assay and other tests. Data are stored securely, and the study will compare predicted responses with actual clinical outcomes to validate the tests usefulness. Participants involvement may last up to a year, with ongoing monitoring and data collection to support personalized therapy development.
CONDITIONS
Brief Title
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
Research Team
V
Valentin S. Schäfer, MD
S
Simon M. Petzinna, MD
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