Predicting Functional Improvement and Complications After Transcatheter Aortic Valve Implantation Using Clinical and Exercise Testing Parameters

What this Trial Is About

This research focuses on patients with severe aortic stenosis who are scheduled to undergo Transcatheter Aortic Valve Implantation TAVI, a less invasive alternative to surgical valve replacement. The study aims to understand how TAVI affects patients exercise capacity and to identify clinical and cardiopulmonary exercise testing CPET parameters that predict improvement in functional capacity after the procedure. Researchers will explore both clinical factors like symptoms and quality of life, as well as functional factors from CPET that influence recovery. Participants will be assessed using an incremental CPET performed on a cycle ergometer, supervised by medical professionals. Testing will occur twice once within two weeks before the TAVI procedure and again 4 to 6 weeks afterward. The study will include 161 patients across three expert centers who meet the criteria for transfemoral TAVI, and it will evaluate both the exercise tolerance response and potential complications related to the procedure. Throughout the study, participants will undergo clinical and functional evaluations before and after TAVI, including detailed CPET assessments to measure changes in VO2 max and anaerobic threshold. Researchers will also monitor quality of life improvements and in-hospital complications. The total participation duration spans from the pre-TAVI assessment through the post-TAVI follow-up at 4 to 6 weeks, during which various clinical and functional outcomes will be measured and analyzed.

Clinical and CPET Parameters That Predict Improvement in Functional Capacity After TAVI