Actively Recruiting
Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC (RERUN)
Led by Daiichi Sankyo · Updated on 2025-05-28
150
Participants Needed
23
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trastuzumab deruxtecan (T-DXd) is an approved therapy for non-small cell lung cancer (NSCLC) in China. Despite the clinical trial evidence, there is no real-world data of T-DXd used in Chinese lung cancer patients with HER2 mutations. This real world, prospective study will assess the effectiveness and safety of T-DXd in patients with locally advanced or metastatic, HER2 mutation-positive NSCLC in real-world setting.
CONDITIONS
Official Title
Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC (RERUN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at signing informed consent form
- Pathologically confirmed unresectable and/or metastatic non-squamous non-small cell lung cancer
- Documented activating HER2 mutation
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Receiving trastuzumab deruxtecan treatment based on physician's decision, started no longer than 2 months before enrollment
You will not qualify if you...
- Prior treatment with HER2-targeted therapies, including TKIs targeting HER2 mutations except pan-HER class TKIs
- Prior treatment with antibody-drug conjugates containing topoisomerase I targeting chemotherapy
- Presence of spinal cord compression or clinically active CNS metastases that are untreated, symptomatic, or require corticosteroids or anticonvulsants
- Evidence of severe or uncontrolled systemic diseases, such as uncontrolled hypertension or active bleeding disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 23 locations
1
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, China, 100021
Not Yet Recruiting
2
Peking University International Hospital
Beijing, China, 100125
Not Yet Recruiting
3
Beijing Cancer Hospital
Beijing, China, 100142
Not Yet Recruiting
4
Hunan Second People's Hospital
Changsha, China, 410007
Not Yet Recruiting
5
Fujian Cancer Hospital
Fuzhou, China, 350014
Not Yet Recruiting
6
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, China, 510060
Not Yet Recruiting
7
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China, 510062
Not Yet Recruiting
8
Zhejiang Cancer Hospital
Hangzhou, China, 310022
Not Yet Recruiting
9
Anhui Provincial Cancer Hospital
Hefei, China, 230031
Not Yet Recruiting
10
First Affiliated Hospital of Shandong First Medical University
Jinan, China, 250014
Not Yet Recruiting
11
Cancer Hospital of Shandong First Medical University
Jinan, China, 250103
Not Yet Recruiting
12
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, China, 121001
Not Yet Recruiting
13
The First Affiliated Hospital of Nanchang University
Nanchang, China, 330000
Not Yet Recruiting
14
Guangxi Medical University Cancer Hospital
Nanning, China, 541000
Not Yet Recruiting
15
Ruijin Hospital, Shanghai Jiaotong University School Of Medicine
Shanghai, China, 200025
Not Yet Recruiting
16
Zhongshan Hospital Fudan University
Shanghai, China, 200032
Not Yet Recruiting
17
The First Hospital of China Medical University
Shenyang, China, 110001
Not Yet Recruiting
18
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
Shenzhen, China, 518116
Not Yet Recruiting
19
The Fourth Hospital of Hebei Medical University
Shijiazhuang, China, 050011
Not Yet Recruiting
20
Shangxi Provincial Cancer Hospital
Taiyuan, China, 030013
Actively Recruiting
21
The First Affiliated Hospital of Xiamen University
Xiamen, China, 361102
Not Yet Recruiting
22
Henan Cancer Hospital
Zhengzhou, China, 450052
Not Yet Recruiting
23
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China, 450052
Not Yet Recruiting
Research Team
C
Contact for Clinical Trial Information
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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