Evaluating the Effect of Platelet Storage Time on Bleeding in Adults with Hematological Cancers and Severe Thrombocytopenia

What this Trial Is About

Researchers are studying the impact of how long platelet concentrates are stored on bleeding events in patients with blood cancers who need preventive platelet transfusions. The study focuses on patients with severe low platelet counts due to bone marrow failure associated with their disease or treatment. It aims to compare bleeding events based on whether platelet concentrates are stored for more or less than 5 days, as this has not been previously evaluated in detail. Participants will receive platelet transfusions as needed, and after each transfusion, they will self-assess any bleeding events daily using a scale adapted from the World Health Organization. This self-assessment continues until the next transfusion or for up to 10 days. The study is observational and does not involve experimental treatments but monitors standard transfusion practices. During the study, patients will track bleeding events to help researchers measure the occurrence of grade 2 or higher bleeding within 7 days after transfusion. The study involves regular monitoring through self-assessments, and participants must be able to perform these evaluations themselves. The study is expected to run until July 2028 and is led by a university hospital in France.

Clinical Efficacy of Platelet Transfusion