Actively Recruiting
The Clinical Efficacy and Safety of Intratumoral Injection of Chemotherapy for Advanced Solid Tumors
Led by Wuxi People's Hospital · Updated on 2024-05-28
200
Participants Needed
1
Research Sites
278 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project intends to investigate the clinical efficacy of intra-tumoural injection of chemotherapeutic agents (e.g. cisplatin, oxaliplatin, etc.)via fine needle aspiration guided by CT or ultrasound in patients with advanced solid cancers to validate the safety and efficacy.
CONDITIONS
Official Title
The Clinical Efficacy and Safety of Intratumoral Injection of Chemotherapy for Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18-75 years
- Histologically or cytologically confirmed diagnosis of advanced solid tumor(s)
- Have progressed on or are not eligible for available standard therapy
- At least one measurable lesion according to RECIST 1.1 criteria
- ECOG score of 0-2 with a lifespan greater than 12 weeks
- Women of childbearing age with a negative pregnancy test within 7 days before treatment
- Use of medically recognized contraceptive methods during treatment and for at least 6 months after last dose
- Voluntary participation with signed informed consent and good compliance
You will not qualify if you...
- Diagnosis of central nervous system leukemia
- White blood cell count greater than or equal to 50 x 10^9/L or rapid disease progression preventing full treatment
- Uncontrollable fungal, bacterial, viral, or other infections requiring isolation
- HIV, HBV, or HCV positive
- Diseases or autoimmune lesions of the central nervous system including stroke, epilepsy, dementia
- Myocardial infarction, cardiac angiography or stents, active angina, or cardiopathic asthma within 12 months
- Use of anticoagulation or severe coagulopathy (APTT >70)
- Systemic corticosteroids or immunosuppressive agents within 2 weeks before investigational drug
- Serious uncontrolled disease or other conditions unsuitable for study treatment as judged by investigator
- Other conditions deemed unsuitable for the study by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wuxi People's Hospital
Wuxi, Jiangsu, China, 214043
Actively Recruiting
Research Team
P
Peihua Lu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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