Actively Recruiting

Phase 2
Age: 0Hours - 24Hours
All Genders
NCT03253263

A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants

Led by OHB Neonatology Ltd. · Updated on 2026-01-07

338

Participants Needed

66

Research Sites

454 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to determine if an investigational drug can prevent Bronchopulmonary Dysplasia, reducing the burden of chronic lung disease in extremely premature infants, as compared to extremely premature infants receiving standard neonatal care alone.

CONDITIONS

Official Title

A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants

Who Can Participate

Age: 0Hours - 24Hours
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Written informed consent must be signed and dated by the participant's parent(s) before any study procedures.
  • Written informed consent must be signed and dated by the participant's birth mother before providing birth and pregnancy medical information.
  • Participants must be between 23 weeks 0 days and 27 weeks 6 days gestational age, inclusive.
Not Eligible

You will not qualify if you...

  • Detectable major or severe congenital malformation before randomization.
  • Known or suspected chromosomal abnormality, genetic disorder, or syndrome before randomization.
  • Persistent hypoglycemia at baseline despite glucose supplementation.
  • Clinically significant neurological disease identified before randomization (hemorrhages confined to the germinal matrix allowed).
  • Any condition or therapy posing a risk or interfering with study compliance or results interpretation.
  • Current or planned participation in another investigational study treatment, device, or procedure.
  • Inability of participant or parent(s) to comply with the protocol or attend long-term follow-up.
  • Birth mother with active COVID-19 infection at birth or history of severe COVID-19 requiring intensive care during pregnancy.
  • Birth mother with known HIV or hepatitis B, C, or E infection.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 66 locations

1

Arkansas Children's Hospital

Little Rock, Arkansas, United States, 72202-3500

Actively Recruiting

2

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States, 72202-3500

Actively Recruiting

3

Children's Hospital of Orange County

California City, California, United States, 92868

Actively Recruiting

4

LAC USC Medical Center

Los Angeles, California, United States, 90033-1804

Active, Not Recruiting

5

Jackson Memorial Hospital

Miami, Florida, United States, 33136-1005

Actively Recruiting

6

Tampa General Hospital

Tampa, Florida, United States, 33606-3571

Actively Recruiting

7

University of Illinois at Chicago

Chicago, Illinois, United States, 60612

Actively Recruiting

8

Riley Hospital for Children

Indianapolis, Indiana, United States, 46202

Actively Recruiting

9

Memorial Hospital of South Bend

South Bend, Indiana, United States, 46601-1078

Actively Recruiting

10

Norton Children's Hospital

Louisville, Kentucky, United States, 40202

Actively Recruiting

11

Ochsner Baptist Medical Center

New Orleans, Louisiana, United States, 70115

Actively Recruiting

12

Tufts Medical Center

Boston, Massachusetts, United States, 02111-1553

Actively Recruiting

13

Boston Children's Hospital

Boston, Massachusetts, United States, 02115

Withdrawn

14

Children's Minnesota - Children's Hospital and Clinics - St. Paul

Saint Paul, Minnesota, United States, 55102

Actively Recruiting

15

Children's Minnesota - Children's Hospital and Clinics

Saint Paul, Minnesota, United States, 55102

Actively Recruiting

16

University of Mississippi Medical Center

Jackson, Mississippi, United States, 39216-4500

Actively Recruiting

17

University of Rochester

Rochester, New York, United States, 14627

Actively Recruiting

18

Maria Fareri Children's Hospital

Valhalla, New York, United States, 10595

Actively Recruiting

19

Nationwide Children's Hospital

Columbus, Ohio, United States, 43205

Not Yet Recruiting

20

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States, 73104

Actively Recruiting

21

Medical University of South Carolina Children Hospital

Charleston, South Carolina, United States, 29425-8908

Actively Recruiting

22

UVA Children's Hospital

Charlottesville, Virginia, United States, 22903

Actively Recruiting

23

Virginia Commonwealth University - Children's Hospital of Richmond at VCU

Richmond, Virginia, United States, 23298-5075

Actively Recruiting

24

Royal Hospital for Women

Randwick, New South Wales, Australia, 2031

Actively Recruiting

25

Royal Women's Hospital

Parkville, Australia, 3052

Actively Recruiting

26

Mater Misericordiae Limited

South Brisbane, Australia, Qld 4101

Actively Recruiting

27

Sainte Justine Hospital

Montreal, Quebec, Canada

Actively Recruiting

28

Mount Sinai Hospital

Toronto, Canada, M5G 1X5

Withdrawn

29

Oulun Yliopistollinen Sairaala

Oulu, Finland, 90220

Actively Recruiting

30

Hôpital Antoine Béclère

Clamart, Hauts-de-Seine, France, 92140

Active, Not Recruiting

31

Groupe Hospitalier Necker Enfants Malades

Paris, France, 75015

Active, Not Recruiting

32

Universitätsklinikum Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106

Withdrawn

33

Universitatsklinikum Leipzig

Leipzig, Saxony, Germany, 04103

Actively Recruiting

34

Klinikum Nürnberg

Nuremberg, Germany, 90479

Actively Recruiting

35

Cork University Maternity Hospital

Cork, Wilton, Ireland, T12YE02

Actively Recruiting

36

Fondazione Policlinico Universitario A Gemelli

Rome, Lazio, Italy, 00168

Actively Recruiting

37

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, Italy, 20122

Actively Recruiting

38

Azienda Ospedaliera Di Padova

Padova, Veneto, Italy, 35128

Actively Recruiting

39

Azienda Ospedaliero-Universitaria Careggi SOD Neonatologia e Terapia Intensiva Neonatale

Florence, Italy, 50134

Actively Recruiting

40

Istituto Giannina Gaslini-Istituto Pediatrico di Ricovero e

Genova, Italy, 16147

Actively Recruiting

41

Presidio Ospedaliero Di Treviso Ca' Foncello

Treviso, Italy, 31100

Actively Recruiting

42

Kagoshima City Hospital

Kagoshima, Kagoshima-ken, Japan, 890-0055

Active, Not Recruiting

43

Nagano Children's Hospital

Azumino, Nagano, Japan, 399-8205

Actively Recruiting

44

Kurashiki Central Hospital

Kurashiki-shi, Okayama-ken, Japan, 710-0052

Actively Recruiting

45

Saitama Medical Center

Kawagoe-shi, Saitama, Japan, 350-8550

Actively Recruiting

46

Showa Medical University Hospital

Tokyo, Japan, 142-8666

Actively Recruiting

47

Tokyo Metropolitan Children's Medical Center

Tokyo, Japan, 183-8561

Actively Recruiting

48

Osaka Women's and Children's Hospital

Izumi, Ôsaka, Japan, 594-1101

Actively Recruiting

49

Maastricht University Medical Center

Maastricht, Limburg, Netherlands, 6229 HX

Actively Recruiting

50

Academisch Medisch Centrum Amsterdam

Amsterdam-Zuidoost, North Holland, Netherlands, 1105 AZ

Actively Recruiting

51

Wilhelmina Children Hospital-University Medical Center Utrecht

Utrecht, Netherlands, 3584 EA

Actively Recruiting

52

Hospital Garcia de Orta

Almada, Portugal, 2801-951

Actively Recruiting

53

Maternidade Alfredo da Costa

Lisbon, Portugal, 1069-089

Actively Recruiting

54

Centro Hospitalar Lisboa

Lisbon, Portugal, 1649-035

Actively Recruiting

55

Centro Materno Infantil do Norte - Centro Hospital Universitario do Porto, E.P.E.

Porto, Portugal, 4050-651

Actively Recruiting

56

Hospital General Universitario Dr. Balmis

Alicante, Spain, 03010

Actively Recruiting

57

Skanes Universitetssjukhus

Lund, Sweden, SE-22185

Completed

58

Karolinska Solna

Stockholm, Sweden, 171 76

Withdrawn

59

Norfolk and Norwich University Hospital

Norwich, Norfolk, United Kingdom, NR4 7UY

Actively Recruiting

60

Ashford and St. Peter's Hospitals NHS Trust - St. Peter's Hospital

Chertsey, Surrey, United Kingdom, KT16 0PZ

Completed

61

University of Cambridge

Cambridge, United Kingdom, CB2 0QQ

Actively Recruiting

62

University Hospital Coventry

Coventry, United Kingdom, CV2 2DX

Actively Recruiting

63

Liverpool Women's Hospital - PPDS

Liverpool, United Kingdom, L69 3BX

Actively Recruiting

64

University College London

London, United Kingdom, NW1 2BU

Withdrawn

65

Chelsea and Westminster NHS Trust

London, United Kingdom, SW3 6JJ

Actively Recruiting

66

St. Mary's Hospital

Manchester, United Kingdom, M13 9WL

Actively Recruiting

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Research Team

O

OHB Contact

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants | DecenTrialz