Actively Recruiting
Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers
Led by ZhanYJ · Updated on 2025-05-21
176
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
Z
ZhanYJ
Lead Sponsor
S
Shanghai Minimally Invasive Surgery Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if acupuncture works to treat mild-to-moderate Alzheimer's disease, as well as the difference of its effect in APOE e4 carriers and non-carriers. It will also learn about the safety of acupuncture. Researchers will compare acupuncture to a placebo (sham acupuncture) to see if acupuncture works to relieve the cognitive impairment and improve the ability of daily living and the quality of life. In addition, the plasma and neuroimaging biomarkers will be included as objective indexes. Participants will: Experience acupuncture or sham acupuncture 3 times per week for 12 weeks, and receive a 52-week follow-up. Visit the clinic at Week 12, Week 38 and Week 64 for checkups and tests.
CONDITIONS
Official Title
Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 50-85 years
- Diagnosed with Alzheimer's disease by NINCDS-ADRDA criteria
- Mild to moderate cognitive impairment based on Chinese MMSE scores (11 to 22 for primary school degree, 11 to 26 for junior high school degree or above)
- MRI confirming hippocampus or medial temporal lobe atrophy with high possibility of Alzheimer's disease
- MTA-scale score ≥2 if under 75 years, or ≥3 if over 75 years
- Voluntarily agree to participate and provide informed consent
You will not qualify if you...
- Cognitive impairment caused by other conditions such as vascular dementia, Lewy body dementia, frontotemporal dementia, hormone or metabolic issues, hypothyroidism, folic acid or vitamin B12 deficiency, delirium, schizophrenia, or depression
- Serious heart, liver, kidney, blood diseases, or severe malnutrition
- Aphasia, unconsciousness, or inability to cooperate due to physical disability
- Contraindications for MRI such as claustrophobia or pacemaker implantation
- Use of anticoagulant treatments like warfarin or heparin
- Pacemaker use or acupuncture treatment within the past 2 weeks
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Shanghai, China, 200032
Actively Recruiting
Research Team
Y
Yijun Zhan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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