Actively Recruiting
CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
Led by Sunnybrook Health Sciences Centre · Updated on 2026-04-24
400
Participants Needed
3
Research Sites
170 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare two types of skin preparation solutions (chlorhexidine gluconate-alcohol solution and povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery for patients having revision arthroplasty surgery of the hip or knee. The main outcome of interest for the definitive study is the need for re-operation for a wound complication or an infection of the prosthetic joint within one year after surgery. For the pilot trial, our main interest is to determine feasibility of a definitive trial. Feasibility outcomes will include: ability to recruit patients, ability to randomize patients, ability to collect complete data, estimate the event rate of our primary outcome, ability to carry out data linkages and determine the accuracy of collected data. Participants will be contacted at two time points after surgery to complete a 5-minute survey: after 30 days, and after 1 year.
CONDITIONS
Official Title
CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Scheduled for aseptic revision total hip or knee arthroplasty with exchange of at least one prosthetic component
You will not qualify if you...
- Revision surgery due to prosthetic joint infection or wound complication
- Known previous prosthetic joint infection in the joint being operated on
- Any current clinical concern for prosthetic joint infection
- Allergy to iodine, chlorhexidine, or alcohol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Royal Victoria Regional Health Centre
Barrie, Ontario, Canada, L4M 6M2
Active, Not Recruiting
2
Health Sciences North
Greater Sudbury, Ontario, Canada, P3E 5J1
Actively Recruiting
3
Sunnybrook Holland Centre
Toronto, Ontario, Canada, M4Y 1H1
Active, Not Recruiting
Research Team
E
Erin Lillie, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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